Morphometric and fine structural study of experimental autoallergic sialadenitis of rat submandibular glands

Mohamed M.H. Sharawy, Stuart C. White

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

To further our understanding of the immunopathologic mechanisms involved in experimental autoallergic sialadenitis of rat submandibular gland (EAS), histometric and fine structural studies were undertaken. Rats were immunized with allogeneic submandibular glands (SMG) emulsified in complete Freund's adjuvant. Control rats were not treated (C) or adjuvant treated (At). The rats were sacrificed 7, 14, 21 and 28 days after immunization and their SMG were processed for light and electron microscopy. Groups "C" and "At" showed normal acini and ducts. The SMG at 14 days showed significant loss of acini and granular ducts, severe lymphocytic infiltration and the appearance of undifferentiated ducts. The cells of the latter showed abundant free ribosomes, few profiles of rer, no secretory granules and in some cells autophagic vacuoles. Pseudopods of many lymphocytes were found in juxtaposition to degenerating parenchymal cells, mast cells and eosinophils. The extralobular ducts were significantly increased at 7, 14, and 21 days. The immunized glands showed evidence of regeneration at 21 and 28 days. Terminal tubule cells, proacinar cells and acinar cells, at various stages of maturation, were found in the regenerating glands.

Original languageEnglish (US)
Pages (from-to)255-269
Number of pages15
JournalVirchows Archiv B Cell Pathology
Volume28
Issue number1
DOIs
StatePublished - Dec 1 1978

Keywords

  • Autoallergy
  • Lymphocyte
  • Regeneration
  • Submandibular gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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