Mouse models for studies of HLA-G functions in basic science and pre-clinical research

Anh Thu Nguyen, Ashwin Ajith, Vera Portik-Dobos, Daniel D. Horuzsko, Laura L Mulloy, Anatolij Horuzsko

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

HLA-G was described originally as a tolerogenic molecule that allows the semiallogeneic fetus to escape from recognition by the maternal immune response. This review will discuss different steps in the study of HLA-G expression and functions in vivo, starting with analyses of expression of the HLA-G gene and its receptors in transgenic mice, and continuing with applications of HLA-G and its receptors in prevention of allograft rejection, transplantation tolerance, and controlling the development of infection. Humanized mouse models have been discussed for developing in vivo studies of HLA-G in physiological and pathological conditions. Collectively, animal models provide an opportunity to evaluate the importance of the interaction between HLA-G and its receptors in terms of its ability to regulate immune responses during maternal-fetal tolerance, survival of allografts, tumor-escape mechanisms, and development of infections when both HLA-G and its receptors are expressed. In addition, in vivo studies on HLA-G also offer novel approaches to achieve a reproducible transplantation tolerance and to develop personalized medicine to prevent allograft rejection.

Original languageEnglish (US)
Pages (from-to)711-719
Number of pages9
JournalHuman Immunology
Volume77
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

HLA-G Antigens
Transplantation Tolerance
Research
Allografts
Mothers
Tumor Escape
Precision Medicine
Infection
Transgenic Mice
Fetus
Animal Models

Keywords

  • HLA-G
  • Humanized mice
  • Transgenic mice
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Mouse models for studies of HLA-G functions in basic science and pre-clinical research. / Nguyen, Anh Thu; Ajith, Ashwin; Portik-Dobos, Vera; Horuzsko, Daniel D.; Mulloy, Laura L; Horuzsko, Anatolij.

In: Human Immunology, Vol. 77, No. 9, 01.09.2016, p. 711-719.

Research output: Contribution to journalArticle

Nguyen, Anh Thu ; Ajith, Ashwin ; Portik-Dobos, Vera ; Horuzsko, Daniel D. ; Mulloy, Laura L ; Horuzsko, Anatolij. / Mouse models for studies of HLA-G functions in basic science and pre-clinical research. In: Human Immunology. 2016 ; Vol. 77, No. 9. pp. 711-719.
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