Mouse models for studies of HLA-G functions in basic science and pre-clinical research

Anh Thu Nguyen-Lefebvre, Ashwin Ajith, Vera Portik-Dobos, Daniel D. Horuzsko, Laura L. Mulloy, Anatolij Horuzsko

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

HLA-G was described originally as a tolerogenic molecule that allows the semiallogeneic fetus to escape from recognition by the maternal immune response. This review will discuss different steps in the study of HLA-G expression and functions in vivo, starting with analyses of expression of the HLA-G gene and its receptors in transgenic mice, and continuing with applications of HLA-G and its receptors in prevention of allograft rejection, transplantation tolerance, and controlling the development of infection. Humanized mouse models have been discussed for developing in vivo studies of HLA-G in physiological and pathological conditions. Collectively, animal models provide an opportunity to evaluate the importance of the interaction between HLA-G and its receptors in terms of its ability to regulate immune responses during maternal-fetal tolerance, survival of allografts, tumor-escape mechanisms, and development of infections when both HLA-G and its receptors are expressed. In addition, in vivo studies on HLA-G also offer novel approaches to achieve a reproducible transplantation tolerance and to develop personalized medicine to prevent allograft rejection.

Original languageEnglish (US)
Pages (from-to)711-719
Number of pages9
JournalHuman Immunology
Volume77
Issue number9
DOIs
StatePublished - Sep 1 2016

Keywords

  • HLA-G
  • Humanized mice
  • Transgenic mice
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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