Mouse models of acute and chronic colitis

Santhakumar Manicassamy, Indumathi Manoharan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Crohn's disease (CD) and ulcerative colitis are two main clinically defined forms of chronic inflammatory bowel disease (IBD). Our understanding of IBD depends largely on rodent models. DSS-induced intestinal inflammation in mice and T cell transfer colitis in SCID mice are most widely used and accepted models that can recapitulate the human diseases. Here, we provide detailed protocols of these two mouse models of experimentally induced intestinal inflammation. We also discuss the protocols for the isolation and analysis of inflammatory T cell from the colon.

Original languageEnglish (US)
Pages (from-to)437-448
Number of pages12
JournalMethods in molecular biology (Clifton, N.J.)
Volume1194
DOIs
StatePublished - 2014

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Colitis
Inflammatory Bowel Diseases
Inflammation
T-Lymphocytes
SCID Mice
Ulcerative Colitis
Crohn Disease
Rodentia
Colon

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mouse models of acute and chronic colitis. / Manicassamy, Santhakumar; Manoharan, Indumathi.

In: Methods in molecular biology (Clifton, N.J.), Vol. 1194, 2014, p. 437-448.

Research output: Contribution to journalArticle

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