Mouse models of diabetic nephropathy

Frank C. Brosius, Charles E. Alpers, Erwin P. Bottinger, Matthew D. Breyer, Thomas M. Coffman, Susan B. Gurley, Raymond C. Harris, Masao Kakoki, Matthias Kretzler, Edward H. Leiter, Moshe Levi, Richard A. McIndoe, Kumar Sharma, Oliver Smithies, Katalin Susztak, Nobuyuki Takahashi, Takamune Takahashi

Research output: Contribution to journalReview article

326 Citations (Scopus)

Abstract

Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of reliable animal models that mimic human disease has delayed the identification of specific factors that cause or predict diabetic nephropathy. The Animal Models of Diabetic Complications Consortium (AMDCC) was created in 2001 by the National Institutes of Health to develop and characterize models of diabetic nephropathy and other complications. This interim report and our online supplement detail the progress made toward that goal, specifically in the development and testing of murine models. Updates are provided on validation criteria for early and advanced diabetic nephropathy, phenotyping methods, the effect of background strain on nephropathy, current best models of diabetic nephropathy, negative models, and views of future directions. AMDCC investigators and other investigators in the field have yet to validate a complete murine model of human diabetic kidney disease. Nonetheless, the critical analysis of existing murine models substantially enhances our understanding of this disease process.

Original languageEnglish (US)
Pages (from-to)2503-2512
Number of pages10
JournalJournal of the American Society of Nephrology
Volume20
Issue number12
DOIs
StatePublished - Dec 1 2009

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Diabetic Nephropathies
Animal Models
Diabetes Complications
Research Personnel
National Institutes of Health (U.S.)
Chronic Kidney Failure

ASJC Scopus subject areas

  • Nephrology

Cite this

Brosius, F. C., Alpers, C. E., Bottinger, E. P., Breyer, M. D., Coffman, T. M., Gurley, S. B., ... Takahashi, T. (2009). Mouse models of diabetic nephropathy. Journal of the American Society of Nephrology, 20(12), 2503-2512. https://doi.org/10.1681/ASN.2009070721

Mouse models of diabetic nephropathy. / Brosius, Frank C.; Alpers, Charles E.; Bottinger, Erwin P.; Breyer, Matthew D.; Coffman, Thomas M.; Gurley, Susan B.; Harris, Raymond C.; Kakoki, Masao; Kretzler, Matthias; Leiter, Edward H.; Levi, Moshe; McIndoe, Richard A.; Sharma, Kumar; Smithies, Oliver; Susztak, Katalin; Takahashi, Nobuyuki; Takahashi, Takamune.

In: Journal of the American Society of Nephrology, Vol. 20, No. 12, 01.12.2009, p. 2503-2512.

Research output: Contribution to journalReview article

Brosius, FC, Alpers, CE, Bottinger, EP, Breyer, MD, Coffman, TM, Gurley, SB, Harris, RC, Kakoki, M, Kretzler, M, Leiter, EH, Levi, M, McIndoe, RA, Sharma, K, Smithies, O, Susztak, K, Takahashi, N & Takahashi, T 2009, 'Mouse models of diabetic nephropathy', Journal of the American Society of Nephrology, vol. 20, no. 12, pp. 2503-2512. https://doi.org/10.1681/ASN.2009070721
Brosius FC, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB et al. Mouse models of diabetic nephropathy. Journal of the American Society of Nephrology. 2009 Dec 1;20(12):2503-2512. https://doi.org/10.1681/ASN.2009070721
Brosius, Frank C. ; Alpers, Charles E. ; Bottinger, Erwin P. ; Breyer, Matthew D. ; Coffman, Thomas M. ; Gurley, Susan B. ; Harris, Raymond C. ; Kakoki, Masao ; Kretzler, Matthias ; Leiter, Edward H. ; Levi, Moshe ; McIndoe, Richard A. ; Sharma, Kumar ; Smithies, Oliver ; Susztak, Katalin ; Takahashi, Nobuyuki ; Takahashi, Takamune. / Mouse models of diabetic nephropathy. In: Journal of the American Society of Nephrology. 2009 ; Vol. 20, No. 12. pp. 2503-2512.
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