Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results

Christopher G. Goetz; Barbara C. Tilley; Stephanie R. Shaftman; Glenn T. Stebbins; Stanley Fahn; Pablo Martinez-Martin; Werner Poewe; Cristina Sampaio; Matthew B. Stern; Richard Dodel; Bruno Dubois; Robert Holloway; Joseph Jankovic; Jaime Kulisevsky; Anthony E. Lang; Andrew Lees; Sue Leurgans; Peter A. LeWitt; David Nyenhuis; C. Warren Olanow; Olivier Rascol; Anette Schrag; Jeanne A. Teresi; Jacobus J. van Hilten; Nancy LaPelle; Pinky Agarwal; Saima Athar; Yvette Bordelan; Helen M. Bronte-Stewart; Richard Camicioli; Kelvin Chou; Wendy Cole; Arif Dalvi; Holly Delgado; Alan Diamond; Jeremy P. Dick; John Duda; Rodger J. Elble; Carol Evans; Virgilio G. Evidente; Hubert H. Fernandez; Susan Fox; Joseph H. Friedman; Robin D. Fross; David Gallagher; Christopher G. Goetz; Deborah Hall; Neal Hermanowicz; Vanessa Hinson; Stacy Horn; Howard Hurtig; Un Jung Kang; Galit Kleiner-Fisman; Olga Klepitskaya; Katie Kompoliti; Eugene C. Lai; Maureen L. Leehey; Iracema Leroi; Kelly E. Lyons; Terry McClain; Steven W. Metzer; Janis Miyasaki; John C. Morgan; Martha Nance; Joanne Nemeth; Rajesh Pahwa; Sotirios A. Parashos; J. S.Jay S. Schneider; Anette Schrag; Kapil Sethi; Lisa M. Shulman; Andrew Siderowf; Monty Silverdale; Tanya Simuni; Mark Stacy; Matthew B. Stern; Robert Malcolm Stewart; Kelly Sullivan; David M. Swope; Pettaruse M. Wadia; Richard W. Walker; Ruth Walker; William J. Weiner; Jill Wiener; Jayne Wilkinson; Joanna M. Wojcieszek; Summer Wolfrath; Frederick Wooten; Allen Wu; Theresa A. Zesiewicz; Richard M. Zweig

doi:10.1002/mds.22340

Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results

Christopher G. Goetz, Barbara C. Tilley, Stephanie R. Shaftman, Glenn T. Stebbins, Stanley Fahn, Pablo Martinez-Martin, Werner Poewe, Cristina Sampaio, Matthew B. Stern, Richard Dodel, Bruno Dubois, Robert Holloway, Joseph Jankovic, Jaime Kulisevsky, Anthony E. Lang, Andrew Lees, Sue Leurgans, Peter A. LeWitt, David Nyenhuis, C. Warren OlanowOlivier Rascol, Anette Schrag, Jeanne A. Teresi, Jacobus J. van Hilten, Nancy LaPelle, Pinky Agarwal, Saima Athar, Yvette Bordelan, Helen M. Bronte-Stewart, Richard Camicioli, Kelvin Chou, Wendy Cole, Arif Dalvi, Holly Delgado, Alan Diamond, Jeremy P. Dick, John Duda, Rodger J. Elble, Carol Evans, Virgilio G. Evidente, Hubert H. Fernandez, Susan Fox, Joseph H. Friedman, Robin D. Fross, David Gallagher, Christopher G. Goetz, Deborah Hall, Neal Hermanowicz, Vanessa Hinson, Stacy Horn, Howard Hurtig, Un Jung Kang, Galit Kleiner-Fisman, Olga Klepitskaya, Katie Kompoliti, Eugene C. Lai, Maureen L. Leehey, Iracema Leroi, Kelly E. Lyons, Terry McClain, Steven W. Metzer, Janis Miyasaki, John C. Morgan, Martha Nance, Joanne Nemeth, Rajesh Pahwa, Sotirios A. Parashos, J. S.Jay S. Schneider, Anette Schrag, Kapil Sethi, Lisa M. Shulman, Andrew Siderowf, Monty Silverdale, Tanya Simuni, Mark Stacy, Matthew B. Stern, Robert Malcolm Stewart, Kelly Sullivan, David M. Swope, Pettaruse M. Wadia, Richard W. Walker, Ruth Walker, William J. Weiner, Jill Wiener, Jayne Wilkinson, Joanna M. Wojcieszek, Summer Wolfrath, Frederick Wooten, Allen Wu, Theresa A. Zesiewicz, Richard M. Zweig

Neurology

Research output: Contribution to journal › Article › peer-review

4512 Scopus citations

Abstract

We present a clinimetric assessment of the Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The MDS-UDPRS Task Force revised and expanded the UPDRS using recommendations from a published critique. The MDS-UPDRS has four parts, namely, I: Non-motor Experiences of Daily Living; II: Motor Experiences of Daily Living; III: Motor Examination; IV: Motor Complications. Twenty questions are completed by the patient/caregiver. Item-specific instructions and an appendix of complementary additional scales are provided. Movement disorder specialists and study coordinators administered the UPDRS (55 items) and MDS-UPDRS (65 items) to 877 English speaking (78% non-Latino Caucasian) patients with Parkinson's disease from 39 sites. We compared the two scales using correlative techniques and factor analysis. The MDS-UPDRS showed high internal consistency (Cronbach's alpha 5 0.79-0.93 across parts) and correlated with the original UPDRS (p 5 0.96). MDS-UPDRS across-part correlations ranged from 0.22 to 0.66. Reliable factor structures for each part were obtained (comparative fit index > 0.90 for each part), which support the use of sum scores for each part in preference to a total score of all parts. The combined clinimetric results of this study support the validity of the MDS-UPDRS for rating PD.

Original language	English (US)
Pages (from-to)	2129-2170
Number of pages	42
Journal	Movement Disorders
Volume	23
Issue number	15
DOIs	https://doi.org/10.1002/mds.22340
State	Published - Nov 15 2008

Keywords

Clinimetrics
Parkinson's disease
Rating scales
UPDRS

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.22340

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Goetz, C. G., Tilley, B. C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez-Martin, P., Poewe, W., Sampaio, C., Stern, M. B., Dodel, R., Dubois, B., Holloway, R., Jankovic, J., Kulisevsky, J., Lang, A. E., Lees, A., Leurgans, S., LeWitt, P. A., Nyenhuis, D., ... Zweig, R. M. (2008). Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results. Movement Disorders, 23(15), 2129-2170. https://doi.org/10.1002/mds.22340

Goetz, CG, Tilley, BC, Shaftman, SR, Stebbins, GT, Fahn, S, Martinez-Martin, P, Poewe, W, Sampaio, C, Stern, MB, Dodel, R, Dubois, B, Holloway, R, Jankovic, J, Kulisevsky, J, Lang, AE, Lees, A, Leurgans, S, LeWitt, PA, Nyenhuis, D, Olanow, CW, Rascol, O, Schrag, A, Teresi, JA, van Hilten, JJ, LaPelle, N, Agarwal, P, Athar, S, Bordelan, Y, Bronte-Stewart, HM, Camicioli, R, Chou, K, Cole, W, Dalvi, A, Delgado, H, Diamond, A, Dick, JP, Duda, J, Elble, RJ, Evans, C, Evidente, VG, Fernandez, HH, Fox, S, Friedman, JH, Fross, RD, Gallagher, D, Goetz, CG, Hall, D, Hermanowicz, N, Hinson, V, Horn, S, Hurtig, H, Kang, UJ, Kleiner-Fisman, G, Klepitskaya, O, Kompoliti, K, Lai, EC, Leehey, ML, Leroi, I, Lyons, KE, McClain, T, Metzer, SW, Miyasaki, J, Morgan, JC, Nance, M, Nemeth, J, Pahwa, R, Parashos, SA, Schneider, JSJS, Schrag, A, Sethi, K, Shulman, LM, Siderowf, A, Silverdale, M, Simuni, T, Stacy, M, Stern, MB, Stewart, RM, Sullivan, K, Swope, DM, Wadia, PM, Walker, RW, Walker, R, Weiner, WJ, Wiener, J, Wilkinson, J, Wojcieszek, JM, Wolfrath, S, Wooten, F, Wu, A, Zesiewicz, TA & Zweig, RM 2008, 'Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results', Movement Disorders, vol. 23, no. 15, pp. 2129-2170. https://doi.org/10.1002/mds.22340

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abstract = "We present a clinimetric assessment of the Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The MDS-UDPRS Task Force revised and expanded the UPDRS using recommendations from a published critique. The MDS-UPDRS has four parts, namely, I: Non-motor Experiences of Daily Living; II: Motor Experiences of Daily Living; III: Motor Examination; IV: Motor Complications. Twenty questions are completed by the patient/caregiver. Item-specific instructions and an appendix of complementary additional scales are provided. Movement disorder specialists and study coordinators administered the UPDRS (55 items) and MDS-UPDRS (65 items) to 877 English speaking (78% non-Latino Caucasian) patients with Parkinson's disease from 39 sites. We compared the two scales using correlative techniques and factor analysis. The MDS-UPDRS showed high internal consistency (Cronbach's alpha 5 0.79-0.93 across parts) and correlated with the original UPDRS (p 5 0.96). MDS-UPDRS across-part correlations ranged from 0.22 to 0.66. Reliable factor structures for each part were obtained (comparative fit index > 0.90 for each part), which support the use of sum scores for each part in preference to a total score of all parts. The combined clinimetric results of this study support the validity of the MDS-UPDRS for rating PD.",

keywords = "Clinimetrics, Parkinson's disease, Rating scales, UPDRS",

author = "Goetz, {Christopher G.} and Tilley, {Barbara C.} and Shaftman, {Stephanie R.} and Stebbins, {Glenn T.} and Stanley Fahn and Pablo Martinez-Martin and Werner Poewe and Cristina Sampaio and Stern, {Matthew B.} and Richard Dodel and Bruno Dubois and Robert Holloway and Joseph Jankovic and Jaime Kulisevsky and Lang, {Anthony E.} and Andrew Lees and Sue Leurgans and LeWitt, {Peter A.} and David Nyenhuis and Olanow, {C. Warren} and Olivier Rascol and Anette Schrag and Teresi, {Jeanne A.} and {van Hilten}, {Jacobus J.} and Nancy LaPelle and Pinky Agarwal and Saima Athar and Yvette Bordelan and Bronte-Stewart, {Helen M.} and Richard Camicioli and Kelvin Chou and Wendy Cole and Arif Dalvi and Holly Delgado and Alan Diamond and Dick, {Jeremy P.} and John Duda and Elble, {Rodger J.} and Carol Evans and Evidente, {Virgilio G.} and Fernandez, {Hubert H.} and Susan Fox and Friedman, {Joseph H.} and Fross, {Robin D.} and David Gallagher and Goetz, {Christopher G.} and Deborah Hall and Neal Hermanowicz and Vanessa Hinson and Stacy Horn and Howard Hurtig and Kang, {Un Jung} and Galit Kleiner-Fisman and Olga Klepitskaya and Katie Kompoliti and Lai, {Eugene C.} and Leehey, {Maureen L.} and Iracema Leroi and Lyons, {Kelly E.} and Terry McClain and Metzer, {Steven W.} and Janis Miyasaki and Morgan, {John C.} and Martha Nance and Joanne Nemeth and Rajesh Pahwa and Parashos, {Sotirios A.} and Schneider, {J. S.Jay S.} and Anette Schrag and Kapil Sethi and Shulman, {Lisa M.} and Andrew Siderowf and Monty Silverdale and Tanya Simuni and Mark Stacy and Stern, {Matthew B.} and Stewart, {Robert Malcolm} and Kelly Sullivan and Swope, {David M.} and Wadia, {Pettaruse M.} and Walker, {Richard W.} and Ruth Walker and Weiner, {William J.} and Jill Wiener and Jayne Wilkinson and Wojcieszek, {Joanna M.} and Summer Wolfrath and Frederick Wooten and Allen Wu and Zesiewicz, {Theresa A.} and Zweig, {Richard M.}",

year = "2008",

month = nov,

day = "15",

doi = "10.1002/mds.22340",

language = "English (US)",

volume = "23",

pages = "2129--2170",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley and Sons Inc.",

number = "15",

}

TY - JOUR

T1 - Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS)

T2 - Scale presentation and clinimetric testing results

AU - Goetz, Christopher G.

AU - Tilley, Barbara C.

AU - Shaftman, Stephanie R.

AU - Stebbins, Glenn T.

AU - Fahn, Stanley

AU - Martinez-Martin, Pablo

AU - Poewe, Werner

AU - Sampaio, Cristina

AU - Stern, Matthew B.

AU - Dodel, Richard

AU - Dubois, Bruno

AU - Holloway, Robert

AU - Jankovic, Joseph

AU - Kulisevsky, Jaime

AU - Lang, Anthony E.

AU - Lees, Andrew

AU - Leurgans, Sue

AU - LeWitt, Peter A.

AU - Nyenhuis, David

AU - Olanow, C. Warren

AU - Rascol, Olivier

AU - Schrag, Anette

AU - Teresi, Jeanne A.

AU - van Hilten, Jacobus J.

AU - LaPelle, Nancy

AU - Agarwal, Pinky

AU - Athar, Saima

AU - Bordelan, Yvette

AU - Bronte-Stewart, Helen M.

AU - Camicioli, Richard

AU - Chou, Kelvin

AU - Cole, Wendy

AU - Dalvi, Arif

AU - Delgado, Holly

AU - Diamond, Alan

AU - Dick, Jeremy P.

AU - Duda, John

AU - Elble, Rodger J.

AU - Evans, Carol

AU - Evidente, Virgilio G.

AU - Fernandez, Hubert H.

AU - Fox, Susan

AU - Friedman, Joseph H.

AU - Fross, Robin D.

AU - Gallagher, David

AU - Goetz, Christopher G.

AU - Hall, Deborah

AU - Hermanowicz, Neal

AU - Hinson, Vanessa

AU - Horn, Stacy

AU - Hurtig, Howard

AU - Kang, Un Jung

AU - Kleiner-Fisman, Galit

AU - Klepitskaya, Olga

AU - Kompoliti, Katie

AU - Lai, Eugene C.

AU - Leehey, Maureen L.

AU - Leroi, Iracema

AU - Lyons, Kelly E.

AU - McClain, Terry

AU - Metzer, Steven W.

AU - Miyasaki, Janis

AU - Morgan, John C.

AU - Nance, Martha

AU - Nemeth, Joanne

AU - Pahwa, Rajesh

AU - Parashos, Sotirios A.

AU - Schneider, J. S.Jay S.

AU - Schrag, Anette

AU - Sethi, Kapil

AU - Shulman, Lisa M.

AU - Siderowf, Andrew

AU - Silverdale, Monty

AU - Simuni, Tanya

AU - Stacy, Mark

AU - Stern, Matthew B.

AU - Stewart, Robert Malcolm

AU - Sullivan, Kelly

AU - Swope, David M.

AU - Wadia, Pettaruse M.

AU - Walker, Richard W.

AU - Walker, Ruth

AU - Weiner, William J.

AU - Wiener, Jill

AU - Wilkinson, Jayne

AU - Wojcieszek, Joanna M.

AU - Wolfrath, Summer

AU - Wooten, Frederick

AU - Wu, Allen

AU - Zesiewicz, Theresa A.

AU - Zweig, Richard M.

PY - 2008/11/15

Y1 - 2008/11/15

N2 - We present a clinimetric assessment of the Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The MDS-UDPRS Task Force revised and expanded the UPDRS using recommendations from a published critique. The MDS-UPDRS has four parts, namely, I: Non-motor Experiences of Daily Living; II: Motor Experiences of Daily Living; III: Motor Examination; IV: Motor Complications. Twenty questions are completed by the patient/caregiver. Item-specific instructions and an appendix of complementary additional scales are provided. Movement disorder specialists and study coordinators administered the UPDRS (55 items) and MDS-UPDRS (65 items) to 877 English speaking (78% non-Latino Caucasian) patients with Parkinson's disease from 39 sites. We compared the two scales using correlative techniques and factor analysis. The MDS-UPDRS showed high internal consistency (Cronbach's alpha 5 0.79-0.93 across parts) and correlated with the original UPDRS (p 5 0.96). MDS-UPDRS across-part correlations ranged from 0.22 to 0.66. Reliable factor structures for each part were obtained (comparative fit index > 0.90 for each part), which support the use of sum scores for each part in preference to a total score of all parts. The combined clinimetric results of this study support the validity of the MDS-UPDRS for rating PD.

AB - We present a clinimetric assessment of the Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The MDS-UDPRS Task Force revised and expanded the UPDRS using recommendations from a published critique. The MDS-UPDRS has four parts, namely, I: Non-motor Experiences of Daily Living; II: Motor Experiences of Daily Living; III: Motor Examination; IV: Motor Complications. Twenty questions are completed by the patient/caregiver. Item-specific instructions and an appendix of complementary additional scales are provided. Movement disorder specialists and study coordinators administered the UPDRS (55 items) and MDS-UPDRS (65 items) to 877 English speaking (78% non-Latino Caucasian) patients with Parkinson's disease from 39 sites. We compared the two scales using correlative techniques and factor analysis. The MDS-UPDRS showed high internal consistency (Cronbach's alpha 5 0.79-0.93 across parts) and correlated with the original UPDRS (p 5 0.96). MDS-UPDRS across-part correlations ranged from 0.22 to 0.66. Reliable factor structures for each part were obtained (comparative fit index > 0.90 for each part), which support the use of sum scores for each part in preference to a total score of all parts. The combined clinimetric results of this study support the validity of the MDS-UPDRS for rating PD.

KW - Clinimetrics

KW - Parkinson's disease

KW - Rating scales

KW - UPDRS

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DO - 10.1002/mds.22340

M3 - Article

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AN - SCOPUS:61449165975

SN - 0885-3185

VL - 23

SP - 2129

EP - 2170

JO - Movement Disorders

JF - Movement Disorders

IS - 15

ER -

Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results

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