Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results

Christopher G. Goetz, Barbara C. Tilley, Stephanie R. Shaftman, Glenn T. Stebbins, Stanley Fahn, Pablo Martinez-Martin, Werner Poewe, Cristina Sampaio, Matthew B. Stern, Richard Dodel, Bruno Dubois, Robert Holloway, Joseph Jankovic, Jaime Kulisevsky, Anthony E. Lang, Andrew Lees, Sue Leurgans, Peter A. LeWitt, David Nyenhuis, C. Warren OlanowOlivier Rascol, Anette Schrag, Jeanne A. Teresi, Jacobus J. van Hilten, Nancy LaPelle, Pinky Agarwal, Saima Athar, Yvette Bordelan, Helen M. Bronte-Stewart, Richard Camicioli, Kelvin Chou, Wendy Cole, Arif Dalvi, Holly Delgado, Alan Diamond, Jeremy P. Dick, John Duda, Rodger J. Elble, Carol Evans, Virgilio G. Evidente, Hubert H. Fernandez, Susan Fox, Joseph H. Friedman, Robin D. Fross, David Gallagher, Christopher G. Goetz, Deborah Hall, Neal Hermanowicz, Vanessa Hinson, Stacy Horn, Howard Hurtig, Un Jung Kang, Galit Kleiner-Fisman, Olga Klepitskaya, Katie Kompoliti, Eugene C. Lai, Maureen L. Leehey, Iracema Leroi, Kelly E. Lyons, Terry McClain, Steven W. Metzer, Janis Miyasaki, John C. Morgan, Martha Nance, Joanne Nemeth, Rajesh Pahwa, Sotirios A. Parashos, J. S.Jay S. Schneider, Anette Schrag, Kapil Sethi, Lisa M. Shulman, Andrew Siderowf, Monty Silverdale, Tanya Simuni, Mark Stacy, Matthew B. Stern, Robert Malcolm Stewart, Kelly Sullivan, David M. Swope, Pettaruse M. Wadia, Richard W. Walker, Ruth Walker, William J. Weiner, Jill Wiener, Jayne Wilkinson, Joanna M. Wojcieszek, Summer Wolfrath, Frederick Wooten, Allen Wu, Theresa A. Zesiewicz, Richard M. Zweig

Research output: Contribution to journalArticle

2047 Scopus citations

Abstract

We present a clinimetric assessment of the Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The MDS-UDPRS Task Force revised and expanded the UPDRS using recommendations from a published critique. The MDS-UPDRS has four parts, namely, I: Non-motor Experiences of Daily Living; II: Motor Experiences of Daily Living; III: Motor Examination; IV: Motor Complications. Twenty questions are completed by the patient/caregiver. Item-specific instructions and an appendix of complementary additional scales are provided. Movement disorder specialists and study coordinators administered the UPDRS (55 items) and MDS-UPDRS (65 items) to 877 English speaking (78% non-Latino Caucasian) patients with Parkinson's disease from 39 sites. We compared the two scales using correlative techniques and factor analysis. The MDS-UPDRS showed high internal consistency (Cronbach's alpha 5 0.79-0.93 across parts) and correlated with the original UPDRS (p 5 0.96). MDS-UPDRS across-part correlations ranged from 0.22 to 0.66. Reliable factor structures for each part were obtained (comparative fit index > 0.90 for each part), which support the use of sum scores for each part in preference to a total score of all parts. The combined clinimetric results of this study support the validity of the MDS-UPDRS for rating PD.

Original languageEnglish (US)
Pages (from-to)2129-2170
Number of pages42
JournalMovement Disorders
Volume23
Issue number15
DOIs
StatePublished - Nov 15 2008

Keywords

  • Clinimetrics
  • Parkinson's disease
  • Rating scales
  • UPDRS

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Goetz, C. G., Tilley, B. C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez-Martin, P., Poewe, W., Sampaio, C., Stern, M. B., Dodel, R., Dubois, B., Holloway, R., Jankovic, J., Kulisevsky, J., Lang, A. E., Lees, A., Leurgans, S., LeWitt, P. A., Nyenhuis, D., ... Zweig, R. M. (2008). Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results. Movement Disorders, 23(15), 2129-2170. https://doi.org/10.1002/mds.22340