MRI of normal and pathologic skeletal muscle

W. A. Murphy, W. G. Totty, James Edwin Carroll

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Lower extremity skeletal muscle of 22 individuals (five normal volunteers and 17 patients with muscular or neuromuscular diseases) was studied with magnetic resonance imaging. Axial images generated with spin-echo pulse sequences using short repetition times (500-900 msec TR) and short echo times (30-60 msec TE) provided excellent contrast between fat (high signal intensity) and muscle (intermediate signal intensity). Seventeen patients with clinically verified muscle disorders were evaluated in a manner similar to the normal volunteers. Conditions studied include Duchenne muscular dystrophy (three patients), limb-girdle muscular dystrophy (five), facioscapulohumeral dystrophy (three), and spinal muscular atrophy, amyotrophic lateral sclerosis, hereditary sensorimotor neuropathy, cerebral palsy, poliomyelitis, and Kearn-Sayre mitochondrial muscle disease (one each). General patterns of muscle abnormality were common among the diseases and included decreased or increased muscle size and a spectrum of muscle replacement by fat. Variable patterns were observed within disease groups and for each patient. Much phosphorus-31 spectroscopy has been performed in a blind fashion with no proton map of normal/abnormal muscle distribution to guide the spectroscopist. This study emphasizes the worth of having a muscle proton map of patients with muscle dysfunction to assure that meaningful phosphorus spectroscopic information is obtained from a volume of tissue limited to an appropriate muscle.

Original languageEnglish (US)
Pages (from-to)565-574
Number of pages10
JournalAmerican Journal of Roentgenology
Volume146
Issue number3
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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Skeletal Muscle
Muscles
Muscular Diseases
Phosphorus
Protons
Healthy Volunteers
Fats
Limb-Girdle Muscular Dystrophies
Spinal Muscular Atrophy
Mitochondrial Diseases
Neuromuscular Diseases
Duchenne Muscular Dystrophy
Amyotrophic Lateral Sclerosis
Poliomyelitis
Cerebral Palsy
Lower Extremity
Spectrum Analysis
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

MRI of normal and pathologic skeletal muscle. / Murphy, W. A.; Totty, W. G.; Carroll, James Edwin.

In: American Journal of Roentgenology, Vol. 146, No. 3, 01.01.1986, p. 565-574.

Research output: Contribution to journalArticle

Murphy, W. A. ; Totty, W. G. ; Carroll, James Edwin. / MRI of normal and pathologic skeletal muscle. In: American Journal of Roentgenology. 1986 ; Vol. 146, No. 3. pp. 565-574.
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