Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. I. Study design, procedures, and management

Alan M. Polson, Steven Garrett, Norman H. Stoller, Carl L. Bandt, Philip Jerry Hanes, William J. Killoy, Charles Q. Harrold, G. Lee Southard, Susan P. Duke

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The design and conduct of a 9-month multi-center clinical trial to evaluate the safety and efficacy of subgingivally delivered 5% sanguinarium chloride (SC) and 10% doxycycline hyclate (DH) from a biodegradable drug delivery system in the treatment of adult periodontitis is described. The 3-group randomized study of 180 adults with moderate to severe periodontitis was a modified double-blind parallel design. One group received DH, one group received SC, and the other group received the vehicle control (VC). Patients selected had two quadrants with a minimum of four periodontal pockets ≤5 mm in depth with two sites ≤7 mm. All qualifying sites exhibited bleeding on gentle probing. Qualifying sites were treated at baseline and again at 4 months. Clinical response was assessed by measuring attachment level, probing depth, and bleeding on probing at monthly examinations at qualifying sites and the entire dentition. The plaque index was measured monthly to verify oral hygiene status. The parallel design afforded the opportunity to distinguish between treatment effectiveness of SC, DH, and VC independent of possible crossover effects. Also the effectiveness of oral hygiene in untreated sites of the mouth could be evaluated. Finally, treatment effects in moderate (5 to 6 mm) and deep (≤7 mm) pockets in both treated and untreated sites could be compared. The design was capable of simulating a periodontal practice maintenance program and assessing the response according to maintenance and treatment history. Study management procedures that emphasized center examiner and therapist training and adherence to protocol and procedures to reduce variability are described.

Original languageEnglish (US)
Pages (from-to)110-118
Number of pages9
JournalJournal of Periodontology
Volume68
Issue number2
DOIs
StatePublished - Jan 1 1997

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Keywords

  • clinical trials
  • doxycycline/therapeutic use
  • drug delivery systems, biodegradable
  • follow-up studies
  • multi-center studies
  • periodontitis/therapy
  • sanguinarium chloride/therapeutic use

ASJC Scopus subject areas

  • Periodontics

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