Multilaboratory testing of antifungal combinations against a quality control isolate of Candida krusei

Vishnu Chaturvedi, Rama Ramani, Mahmoud A. Ghannoum, Scott B. Killian, Nicole Holliday, Cindy Knapp, Luis Ostrosky-Zeichner, Shawn A. Messer, Michael A. Pfaller, Naureen J. Iqbal, Beth A. Arthington-Skaggs, Jose A. Vazquez, Tin Sein, John H. Rex, Thomas J. Walsh

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Candida krusei ATCC 6258 was tested by eight laboratories using 96-well plates containing checkerboard pairwise combinations of amphotericin B (AMB), posaconazole (PSC), caspofungin (CSP), and voriconazole (VRC). The methodology led to reproducible results across the laboratories. All drug combinations yielded MICs lower than the MICs of any two drugs tested singly, and combinations of AMB, PSC, CSP, and VRC were indifferent (no antagonism) by summations of fractional inhibitory concentration.

Original languageEnglish (US)
Pages (from-to)1500-1502
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number4
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Chaturvedi, V., Ramani, R., Ghannoum, M. A., Killian, S. B., Holliday, N., Knapp, C., Ostrosky-Zeichner, L., Messer, S. A., Pfaller, M. A., Iqbal, N. J., Arthington-Skaggs, B. A., Vazquez, J. A., Sein, T., Rex, J. H., & Walsh, T. J. (2008). Multilaboratory testing of antifungal combinations against a quality control isolate of Candida krusei. Antimicrobial Agents and Chemotherapy, 52(4), 1500-1502. https://doi.org/10.1128/AAC.00574-07