Multiple Discordant Histology after Nephrectomy: Descriptive Analysis and Outcomes

Brittani L. Harlow, Zachary W A Klaassen, Sarah Holzman, Lael Reinstatler, Alicia A. Franken, Sravan Kumar Kavuri, Martha Kennedy Terris, Viraj A. Master, Kelvin A. Moses

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background While RCC is the most common primary renal neoplasm, few cases of ipsilateral renal lesions of different RCC histologic subtypes have been described. The objective of this study was to evaluate our experience with synchronous, histologically unique, primary renal neoplasms within the same kidney. Patients and Methods We retrospectively analyzed 2 institutional nephrectomy databases from 2000 to 2013. The study cohort comprised 15 patients with multiple, discordant renal histology after partial or radical nephrectomy. Demographic data, immunohistochemical analysis, and clinical course were assessed and analyzed. Results Eight patients (53%) were black, 10 (60%) were male, and 5 (36%) were tobacco users. Median follow-up time was 13 months (range, 1-62 months), and 9 patients (56%) underwent radical nephrectomy. Among 36 tumors, the median tumor size was 2.3 cm (range, 0.4-9 cm). The most common combination of discordant tumor histology among patients with ≥ 2 tumors was clear-cell (cc) renal-cell carcinoma (RCC) with chromophobe RCC (3 cases, 19%). In 3 patients (19%), a single tumor was noted to have 2 distinct patterns; all patients had ccRCC with papillary RCC. Three (20%) of 15 patients developed metastatic disease. The median cancer-free survival time for patients with metastasis was 2 months. Conclusion Multiple, discordant renal pathology represents a rarely reported entity in patients receiving nephrectomy. We introduce the largest cohort of synchronous renal tumors, of which ccRCC/chromophobe RCC was the most common pairing.

Original languageEnglish (US)
Pages (from-to)e171-e175
JournalClinical Genitourinary Cancer
Volume14
Issue number2
DOIs
StatePublished - Apr 1 2016

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Nephrectomy
Histology
Renal Cell Carcinoma
Kidney
Neoplasms
Kidney Neoplasms
Tobacco
Cohort Studies
Demography
Databases
Pathology
Neoplasm Metastasis
Survival

Keywords

  • Clear-cell renal-cell carcinoma
  • Histology
  • Papillary renal-cell carcinoma
  • Pathology
  • Renal-cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Multiple Discordant Histology after Nephrectomy : Descriptive Analysis and Outcomes. / Harlow, Brittani L.; Klaassen, Zachary W A; Holzman, Sarah; Reinstatler, Lael; Franken, Alicia A.; Kavuri, Sravan Kumar; Terris, Martha Kennedy; Master, Viraj A.; Moses, Kelvin A.

In: Clinical Genitourinary Cancer, Vol. 14, No. 2, 01.04.2016, p. e171-e175.

Research output: Contribution to journalArticle

Harlow, Brittani L. ; Klaassen, Zachary W A ; Holzman, Sarah ; Reinstatler, Lael ; Franken, Alicia A. ; Kavuri, Sravan Kumar ; Terris, Martha Kennedy ; Master, Viraj A. ; Moses, Kelvin A. / Multiple Discordant Histology after Nephrectomy : Descriptive Analysis and Outcomes. In: Clinical Genitourinary Cancer. 2016 ; Vol. 14, No. 2. pp. e171-e175.
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abstract = "Background While RCC is the most common primary renal neoplasm, few cases of ipsilateral renal lesions of different RCC histologic subtypes have been described. The objective of this study was to evaluate our experience with synchronous, histologically unique, primary renal neoplasms within the same kidney. Patients and Methods We retrospectively analyzed 2 institutional nephrectomy databases from 2000 to 2013. The study cohort comprised 15 patients with multiple, discordant renal histology after partial or radical nephrectomy. Demographic data, immunohistochemical analysis, and clinical course were assessed and analyzed. Results Eight patients (53{\%}) were black, 10 (60{\%}) were male, and 5 (36{\%}) were tobacco users. Median follow-up time was 13 months (range, 1-62 months), and 9 patients (56{\%}) underwent radical nephrectomy. Among 36 tumors, the median tumor size was 2.3 cm (range, 0.4-9 cm). The most common combination of discordant tumor histology among patients with ≥ 2 tumors was clear-cell (cc) renal-cell carcinoma (RCC) with chromophobe RCC (3 cases, 19{\%}). In 3 patients (19{\%}), a single tumor was noted to have 2 distinct patterns; all patients had ccRCC with papillary RCC. Three (20{\%}) of 15 patients developed metastatic disease. The median cancer-free survival time for patients with metastasis was 2 months. Conclusion Multiple, discordant renal pathology represents a rarely reported entity in patients receiving nephrectomy. We introduce the largest cohort of synchronous renal tumors, of which ccRCC/chromophobe RCC was the most common pairing.",
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AU - Reinstatler, Lael

AU - Franken, Alicia A.

AU - Kavuri, Sravan Kumar

AU - Terris, Martha Kennedy

AU - Master, Viraj A.

AU - Moses, Kelvin A.

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N2 - Background While RCC is the most common primary renal neoplasm, few cases of ipsilateral renal lesions of different RCC histologic subtypes have been described. The objective of this study was to evaluate our experience with synchronous, histologically unique, primary renal neoplasms within the same kidney. Patients and Methods We retrospectively analyzed 2 institutional nephrectomy databases from 2000 to 2013. The study cohort comprised 15 patients with multiple, discordant renal histology after partial or radical nephrectomy. Demographic data, immunohistochemical analysis, and clinical course were assessed and analyzed. Results Eight patients (53%) were black, 10 (60%) were male, and 5 (36%) were tobacco users. Median follow-up time was 13 months (range, 1-62 months), and 9 patients (56%) underwent radical nephrectomy. Among 36 tumors, the median tumor size was 2.3 cm (range, 0.4-9 cm). The most common combination of discordant tumor histology among patients with ≥ 2 tumors was clear-cell (cc) renal-cell carcinoma (RCC) with chromophobe RCC (3 cases, 19%). In 3 patients (19%), a single tumor was noted to have 2 distinct patterns; all patients had ccRCC with papillary RCC. Three (20%) of 15 patients developed metastatic disease. The median cancer-free survival time for patients with metastasis was 2 months. Conclusion Multiple, discordant renal pathology represents a rarely reported entity in patients receiving nephrectomy. We introduce the largest cohort of synchronous renal tumors, of which ccRCC/chromophobe RCC was the most common pairing.

AB - Background While RCC is the most common primary renal neoplasm, few cases of ipsilateral renal lesions of different RCC histologic subtypes have been described. The objective of this study was to evaluate our experience with synchronous, histologically unique, primary renal neoplasms within the same kidney. Patients and Methods We retrospectively analyzed 2 institutional nephrectomy databases from 2000 to 2013. The study cohort comprised 15 patients with multiple, discordant renal histology after partial or radical nephrectomy. Demographic data, immunohistochemical analysis, and clinical course were assessed and analyzed. Results Eight patients (53%) were black, 10 (60%) were male, and 5 (36%) were tobacco users. Median follow-up time was 13 months (range, 1-62 months), and 9 patients (56%) underwent radical nephrectomy. Among 36 tumors, the median tumor size was 2.3 cm (range, 0.4-9 cm). The most common combination of discordant tumor histology among patients with ≥ 2 tumors was clear-cell (cc) renal-cell carcinoma (RCC) with chromophobe RCC (3 cases, 19%). In 3 patients (19%), a single tumor was noted to have 2 distinct patterns; all patients had ccRCC with papillary RCC. Three (20%) of 15 patients developed metastatic disease. The median cancer-free survival time for patients with metastasis was 2 months. Conclusion Multiple, discordant renal pathology represents a rarely reported entity in patients receiving nephrectomy. We introduce the largest cohort of synchronous renal tumors, of which ccRCC/chromophobe RCC was the most common pairing.

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