Multiple interleukin-1 activities in luteal phase human plasma

J. G. Cannon, C. A. Dinarello

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Correlation of IL-1 levels in the human circulation with various physiological and pathological conditions has been hampered by substances in whole plasma or serum which interfere with the in vitro lymphocyte activation assay. Chromatography over G-50 separates most of the interfering factors from IL-1 activity found in the 4-15 kD molecular weight range. Using this method, IL-1 activity was found consistently in plasma from women in the luteal phase of their menstrual cycle. This investigation provides further evidence that the activity is attributable to IL-1 by demonstrating that whole plasma injected into rats reduced their plasma iron levels and that plasma fractions which activated thymocytes also caused fever when injected into mice.

Original languageEnglish (US)
Pages (from-to)226-229
Number of pages4
JournalBritish Journal of Rheumatology
Volume24
Issue numberSUPPL. 1
StatePublished - Dec 1 1985

Fingerprint

Luteal Phase
Interleukin-1
Thymocytes
Lymphocyte Activation
Chromatography
Fever
Iron
Molecular Weight
Serum

ASJC Scopus subject areas

  • Rheumatology
  • Neuroscience(all)

Cite this

Cannon, J. G., & Dinarello, C. A. (1985). Multiple interleukin-1 activities in luteal phase human plasma. British Journal of Rheumatology, 24(SUPPL. 1), 226-229.

Multiple interleukin-1 activities in luteal phase human plasma. / Cannon, J. G.; Dinarello, C. A.

In: British Journal of Rheumatology, Vol. 24, No. SUPPL. 1, 01.12.1985, p. 226-229.

Research output: Contribution to journalArticle

Cannon, JG & Dinarello, CA 1985, 'Multiple interleukin-1 activities in luteal phase human plasma', British Journal of Rheumatology, vol. 24, no. SUPPL. 1, pp. 226-229.
Cannon, J. G. ; Dinarello, C. A. / Multiple interleukin-1 activities in luteal phase human plasma. In: British Journal of Rheumatology. 1985 ; Vol. 24, No. SUPPL. 1. pp. 226-229.
@article{68d83e365128438b9c1736c8930fc0b0,
title = "Multiple interleukin-1 activities in luteal phase human plasma",
abstract = "Correlation of IL-1 levels in the human circulation with various physiological and pathological conditions has been hampered by substances in whole plasma or serum which interfere with the in vitro lymphocyte activation assay. Chromatography over G-50 separates most of the interfering factors from IL-1 activity found in the 4-15 kD molecular weight range. Using this method, IL-1 activity was found consistently in plasma from women in the luteal phase of their menstrual cycle. This investigation provides further evidence that the activity is attributable to IL-1 by demonstrating that whole plasma injected into rats reduced their plasma iron levels and that plasma fractions which activated thymocytes also caused fever when injected into mice.",
author = "Cannon, {J. G.} and Dinarello, {C. A.}",
year = "1985",
month = "12",
day = "1",
language = "English (US)",
volume = "24",
pages = "226--229",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Multiple interleukin-1 activities in luteal phase human plasma

AU - Cannon, J. G.

AU - Dinarello, C. A.

PY - 1985/12/1

Y1 - 1985/12/1

N2 - Correlation of IL-1 levels in the human circulation with various physiological and pathological conditions has been hampered by substances in whole plasma or serum which interfere with the in vitro lymphocyte activation assay. Chromatography over G-50 separates most of the interfering factors from IL-1 activity found in the 4-15 kD molecular weight range. Using this method, IL-1 activity was found consistently in plasma from women in the luteal phase of their menstrual cycle. This investigation provides further evidence that the activity is attributable to IL-1 by demonstrating that whole plasma injected into rats reduced their plasma iron levels and that plasma fractions which activated thymocytes also caused fever when injected into mice.

AB - Correlation of IL-1 levels in the human circulation with various physiological and pathological conditions has been hampered by substances in whole plasma or serum which interfere with the in vitro lymphocyte activation assay. Chromatography over G-50 separates most of the interfering factors from IL-1 activity found in the 4-15 kD molecular weight range. Using this method, IL-1 activity was found consistently in plasma from women in the luteal phase of their menstrual cycle. This investigation provides further evidence that the activity is attributable to IL-1 by demonstrating that whole plasma injected into rats reduced their plasma iron levels and that plasma fractions which activated thymocytes also caused fever when injected into mice.

UR - http://www.scopus.com/inward/record.url?scp=0022352196&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022352196&partnerID=8YFLogxK

M3 - Article

VL - 24

SP - 226

EP - 229

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - SUPPL. 1

ER -