Multiple metals predict prolactin and thyrotropin (TSH) levels in men

John D. Meeker, Mary G. Rossano, Bridget Protas, Michael Peter Diamond, Elizabeth Puscheck, Douglas Daly, Nigel Paneth, Julia J. Wirth

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Exposure to a number of metals can affect neuroendocrine and thyroid signaling, which can result in adverse effects on development, behavior, metabolism, reproduction, and other functions. The present study assessed the relationship between metal concentrations in blood and serum prolactin (PRL) and thyrotropin (TSH) levels, markers of dopaminergic, and thyroid function, respectively, among men participating in a study of environmental influences on male reproductive health. Blood samples from 219 men were analyzed for concentrations of 11 metals and serum levels of PRL and TSH. In multiple linear regression models adjusted for age, BMI and smoking, PRL was inversely associated with arsenic, cadmium, copper, lead, manganese, molybdenum, and zinc, but positively associated with chromium. Several of these associations (Cd, Pb, Mo) are consistent with limited studies in humans or animals, and a number of the relationships (Cr, Cu, Pb, Mo) remained when additionally considering multiple metals in the model. Lead and copper were associated with non-monotonic decrease in TSH, while arsenic was associated with a dose-dependent increase in TSH. For arsenic these findings were consistent with recent experimental studies where arsenic inhibited enzymes involved in thyroid hormone synthesis and signaling. More research is needed for a better understanding of the role of metals in neuroendocrine and thyroid function and related health implications.

Original languageEnglish (US)
Pages (from-to)869-873
Number of pages5
JournalEnvironmental Research
Volume109
Issue number7
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

Fingerprint

Thyrotropin
Prolactin
Arsenic
Metals
arsenic
metal
Thyroid Gland
Copper
serum
Linear Models
Blood
blood
Health
copper
reproductive health
Molybdenum
Reproductive Health
Chromium
Manganese
molybdenum

Keywords

  • Endocrine
  • Epidemiology
  • Exposure
  • Human
  • Male

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Meeker, J. D., Rossano, M. G., Protas, B., Diamond, M. P., Puscheck, E., Daly, D., ... Wirth, J. J. (2009). Multiple metals predict prolactin and thyrotropin (TSH) levels in men. Environmental Research, 109(7), 869-873. https://doi.org/10.1016/j.envres.2009.06.004

Multiple metals predict prolactin and thyrotropin (TSH) levels in men. / Meeker, John D.; Rossano, Mary G.; Protas, Bridget; Diamond, Michael Peter; Puscheck, Elizabeth; Daly, Douglas; Paneth, Nigel; Wirth, Julia J.

In: Environmental Research, Vol. 109, No. 7, 01.10.2009, p. 869-873.

Research output: Contribution to journalArticle

Meeker, JD, Rossano, MG, Protas, B, Diamond, MP, Puscheck, E, Daly, D, Paneth, N & Wirth, JJ 2009, 'Multiple metals predict prolactin and thyrotropin (TSH) levels in men', Environmental Research, vol. 109, no. 7, pp. 869-873. https://doi.org/10.1016/j.envres.2009.06.004
Meeker, John D. ; Rossano, Mary G. ; Protas, Bridget ; Diamond, Michael Peter ; Puscheck, Elizabeth ; Daly, Douglas ; Paneth, Nigel ; Wirth, Julia J. / Multiple metals predict prolactin and thyrotropin (TSH) levels in men. In: Environmental Research. 2009 ; Vol. 109, No. 7. pp. 869-873.
@article{d377fbca7dd84619acd87750b7d6779b,
title = "Multiple metals predict prolactin and thyrotropin (TSH) levels in men",
abstract = "Exposure to a number of metals can affect neuroendocrine and thyroid signaling, which can result in adverse effects on development, behavior, metabolism, reproduction, and other functions. The present study assessed the relationship between metal concentrations in blood and serum prolactin (PRL) and thyrotropin (TSH) levels, markers of dopaminergic, and thyroid function, respectively, among men participating in a study of environmental influences on male reproductive health. Blood samples from 219 men were analyzed for concentrations of 11 metals and serum levels of PRL and TSH. In multiple linear regression models adjusted for age, BMI and smoking, PRL was inversely associated with arsenic, cadmium, copper, lead, manganese, molybdenum, and zinc, but positively associated with chromium. Several of these associations (Cd, Pb, Mo) are consistent with limited studies in humans or animals, and a number of the relationships (Cr, Cu, Pb, Mo) remained when additionally considering multiple metals in the model. Lead and copper were associated with non-monotonic decrease in TSH, while arsenic was associated with a dose-dependent increase in TSH. For arsenic these findings were consistent with recent experimental studies where arsenic inhibited enzymes involved in thyroid hormone synthesis and signaling. More research is needed for a better understanding of the role of metals in neuroendocrine and thyroid function and related health implications.",
keywords = "Endocrine, Epidemiology, Exposure, Human, Male",
author = "Meeker, {John D.} and Rossano, {Mary G.} and Bridget Protas and Diamond, {Michael Peter} and Elizabeth Puscheck and Douglas Daly and Nigel Paneth and Wirth, {Julia J.}",
year = "2009",
month = "10",
day = "1",
doi = "10.1016/j.envres.2009.06.004",
language = "English (US)",
volume = "109",
pages = "869--873",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press Inc.",
number = "7",

}

TY - JOUR

T1 - Multiple metals predict prolactin and thyrotropin (TSH) levels in men

AU - Meeker, John D.

AU - Rossano, Mary G.

AU - Protas, Bridget

AU - Diamond, Michael Peter

AU - Puscheck, Elizabeth

AU - Daly, Douglas

AU - Paneth, Nigel

AU - Wirth, Julia J.

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Exposure to a number of metals can affect neuroendocrine and thyroid signaling, which can result in adverse effects on development, behavior, metabolism, reproduction, and other functions. The present study assessed the relationship between metal concentrations in blood and serum prolactin (PRL) and thyrotropin (TSH) levels, markers of dopaminergic, and thyroid function, respectively, among men participating in a study of environmental influences on male reproductive health. Blood samples from 219 men were analyzed for concentrations of 11 metals and serum levels of PRL and TSH. In multiple linear regression models adjusted for age, BMI and smoking, PRL was inversely associated with arsenic, cadmium, copper, lead, manganese, molybdenum, and zinc, but positively associated with chromium. Several of these associations (Cd, Pb, Mo) are consistent with limited studies in humans or animals, and a number of the relationships (Cr, Cu, Pb, Mo) remained when additionally considering multiple metals in the model. Lead and copper were associated with non-monotonic decrease in TSH, while arsenic was associated with a dose-dependent increase in TSH. For arsenic these findings were consistent with recent experimental studies where arsenic inhibited enzymes involved in thyroid hormone synthesis and signaling. More research is needed for a better understanding of the role of metals in neuroendocrine and thyroid function and related health implications.

AB - Exposure to a number of metals can affect neuroendocrine and thyroid signaling, which can result in adverse effects on development, behavior, metabolism, reproduction, and other functions. The present study assessed the relationship between metal concentrations in blood and serum prolactin (PRL) and thyrotropin (TSH) levels, markers of dopaminergic, and thyroid function, respectively, among men participating in a study of environmental influences on male reproductive health. Blood samples from 219 men were analyzed for concentrations of 11 metals and serum levels of PRL and TSH. In multiple linear regression models adjusted for age, BMI and smoking, PRL was inversely associated with arsenic, cadmium, copper, lead, manganese, molybdenum, and zinc, but positively associated with chromium. Several of these associations (Cd, Pb, Mo) are consistent with limited studies in humans or animals, and a number of the relationships (Cr, Cu, Pb, Mo) remained when additionally considering multiple metals in the model. Lead and copper were associated with non-monotonic decrease in TSH, while arsenic was associated with a dose-dependent increase in TSH. For arsenic these findings were consistent with recent experimental studies where arsenic inhibited enzymes involved in thyroid hormone synthesis and signaling. More research is needed for a better understanding of the role of metals in neuroendocrine and thyroid function and related health implications.

KW - Endocrine

KW - Epidemiology

KW - Exposure

KW - Human

KW - Male

UR - http://www.scopus.com/inward/record.url?scp=69849109617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69849109617&partnerID=8YFLogxK

U2 - 10.1016/j.envres.2009.06.004

DO - 10.1016/j.envres.2009.06.004

M3 - Article

C2 - 19595304

AN - SCOPUS:69849109617

VL - 109

SP - 869

EP - 873

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

IS - 7

ER -