Multistrain comparison of three antimicrobial prophylaxis regimens in experimental postoperative Pseudomonas endophthaimitis

Rex A. Yannis, J. Peter Rissing, Thomas B. Buxton, Robert K. Shockley

Research output: Contribution to journalArticle

4 Scopus citations


We compared subconjunctivally administered ceftazidime and BMY 28142, two third-generation cephalosporins, to a regimen of gentamicin and cefazolin for their ability to prevent experimental Pseudomonas postoperative endophthalmitis in rabbits. After extracapsular lens extraction, an inoculum of Pseudomonas was injected into the vitreous; one of the three antimicrobial regimens was then administered subconjunctivally. All 25 eyes treated with gentamicin and cefazolin became infected (P = 1). Two of 25 eyes treated with BMY 28142 became infected (P < .001). None of the 25 eyes treated with ceftazidime became infected (P < .001).

Original languageEnglish (US)
Pages (from-to)404-407
Number of pages4
JournalAmerican Journal of Ophthalmology
Issue number3
StatePublished - Sep 15 1985
Externally publishedYes


ASJC Scopus subject areas

  • Ophthalmology

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