We compared subconjunctivally administered ceftazidime and BMY 28142, two third-generation cephalosporins, to a regimen of gentamicin and cefazolin for their ability to prevent experimental Pseudomonas postoperative endophthalmitis in rabbits. After extracapsular lens extraction, an inoculum of Pseudomonas was injected into the vitreous; one of the three antimicrobial regimens was then administered subconjunctivally. All 25 eyes treated with gentamicin and cefazolin became infected (P = 1). Two of 25 eyes treated with BMY 28142 became infected (P < .001). None of the 25 eyes treated with ceftazidime became infected (P < .001).
ASJC Scopus subject areas