Multistrain comparison of three antimicrobial prophylaxis regimens in experimental postoperative Pseudomonas endophthaimitis

Rex A. Yannis; J. Peter Rissing; Thomas B. Buxton; Robert K. Shockley

doi:10.1016/0002-9394(85)90501-X

Multistrain comparison of three antimicrobial prophylaxis regimens in experimental postoperative Pseudomonas endophthaimitis

Rex A. Yannis, J. Peter Rissing, Thomas B. Buxton, Robert K. Shockley

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We compared subconjunctivally administered ceftazidime and BMY 28142, two third-generation cephalosporins, to a regimen of gentamicin and cefazolin for their ability to prevent experimental Pseudomonas postoperative endophthalmitis in rabbits. After extracapsular lens extraction, an inoculum of Pseudomonas was injected into the vitreous; one of the three antimicrobial regimens was then administered subconjunctivally. All 25 eyes treated with gentamicin and cefazolin became infected (P = 1). Two of 25 eyes treated with BMY 28142 became infected (P < .001). None of the 25 eyes treated with ceftazidime became infected (P < .001).

Original language	English (US)
Pages (from-to)	404-407
Number of pages	4
Journal	American Journal of Ophthalmology
Volume	100
Issue number	3
DOIs	https://doi.org/10.1016/0002-9394(85)90501-X
State	Published - Sep 15 1985
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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title = "Multistrain comparison of three antimicrobial prophylaxis regimens in experimental postoperative Pseudomonas endophthaimitis",

abstract = "We compared subconjunctivally administered ceftazidime and BMY 28142, two third-generation cephalosporins, to a regimen of gentamicin and cefazolin for their ability to prevent experimental Pseudomonas postoperative endophthalmitis in rabbits. After extracapsular lens extraction, an inoculum of Pseudomonas was injected into the vitreous; one of the three antimicrobial regimens was then administered subconjunctivally. All 25 eyes treated with gentamicin and cefazolin became infected (P = 1). Two of 25 eyes treated with BMY 28142 became infected (P < .001). None of the 25 eyes treated with ceftazidime became infected (P < .001).",

author = "Yannis, {Rex A.} and {Peter Rissing}, J. and Buxton, {Thomas B.} and Shockley, {Robert K.}",

note = "Funding Information: From the Department of Infectious Disease, Veterans Administration Medical Center, Augusta, Georgia. This study was supported in part by the Veterans Administration Medical Research Service and by a research grant from the Bristol-Meyers Company. Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Florida, May 6, 1985.",

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doi = "10.1016/0002-9394(85)90501-X",

language = "English (US)",

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T1 - Multistrain comparison of three antimicrobial prophylaxis regimens in experimental postoperative Pseudomonas endophthaimitis

AU - Yannis, Rex A.

AU - Peter Rissing, J.

AU - Buxton, Thomas B.

AU - Shockley, Robert K.

N1 - Funding Information: From the Department of Infectious Disease, Veterans Administration Medical Center, Augusta, Georgia. This study was supported in part by the Veterans Administration Medical Research Service and by a research grant from the Bristol-Meyers Company. Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Florida, May 6, 1985.

PY - 1985/9/15

Y1 - 1985/9/15

N2 - We compared subconjunctivally administered ceftazidime and BMY 28142, two third-generation cephalosporins, to a regimen of gentamicin and cefazolin for their ability to prevent experimental Pseudomonas postoperative endophthalmitis in rabbits. After extracapsular lens extraction, an inoculum of Pseudomonas was injected into the vitreous; one of the three antimicrobial regimens was then administered subconjunctivally. All 25 eyes treated with gentamicin and cefazolin became infected (P = 1). Two of 25 eyes treated with BMY 28142 became infected (P < .001). None of the 25 eyes treated with ceftazidime became infected (P < .001).

AB - We compared subconjunctivally administered ceftazidime and BMY 28142, two third-generation cephalosporins, to a regimen of gentamicin and cefazolin for their ability to prevent experimental Pseudomonas postoperative endophthalmitis in rabbits. After extracapsular lens extraction, an inoculum of Pseudomonas was injected into the vitreous; one of the three antimicrobial regimens was then administered subconjunctivally. All 25 eyes treated with gentamicin and cefazolin became infected (P = 1). Two of 25 eyes treated with BMY 28142 became infected (P < .001). None of the 25 eyes treated with ceftazidime became infected (P < .001).

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ER -

Multistrain comparison of three antimicrobial prophylaxis regimens in experimental postoperative Pseudomonas endophthaimitis

Abstract

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