We compared subconjunctivally administered ceftazidime and BMY 28142, two third-generation cephalosporins, to a regimen of gentamicin and cefazolin for their ability to prevent experimental Pseudomonas postoperative endophthalmitis in rabbits. After extracapsular lens extraction, an inoculum of Pseudomonas was injected into the vitreous; one of the three antimicrobial regimens was then administered subconjunctivally. All 25 eyes treated with gentamicin and cefazolin became infected (P = 1). Two of 25 eyes treated with BMY 28142 became infected (P < .001). None of the 25 eyes treated with ceftazidime became infected (P < .001).
|Original language||English (US)|
|Number of pages||4|
|Journal||American Journal of Ophthalmology|
|State||Published - Sep 15 1985|
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