Muscarinic receptors and ligands in cancer

Nirish Shah, Sandeep Khurana, Kunrong Cheng, Jean Pierre Raufman

Research output: Contribution to journalReview article

86 Citations (Scopus)

Abstract

Emerging evidence indi-cates that muscarinic receptors and ligands play key roles in regulating cellular proliferation and cancer progression. Both neuronal and nonneuronal acetylcholine production results in neurocrine, paracrine, and autocrine promotion of cell proliferation, apoptosis, migration, and other features critical for cancer cell survival and spread. The present review comprises a focused critical analysis of evidence supporting the role of muscarinic receptors and ligands in cancer. Criteria are proposed to validate the biological importance of muscarinic receptor expression, activation, and postreceptor signaling. Likewise, criteria are proposed to validate the role of nonneuronal acetylcholine production in cancer. Dissecting cellular mechanisms necessary for muscarinic receptor activation as well as those needed for acetylcholine production and release will identify multiple novel targets for cancer therapy.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Cell Physiology
Volume296
Issue number2
DOIs
StatePublished - Feb 1 2009

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Muscarinic Receptors
Ligands
Acetylcholine
Neoplasms
Cell Proliferation
Cell Survival
Apoptosis

Keywords

  • Acetylcholine
  • Bile acids
  • Cholinergic
  • Signaling
  • Tumor genesis; nonneuronal

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

Cite this

Muscarinic receptors and ligands in cancer. / Shah, Nirish; Khurana, Sandeep; Cheng, Kunrong; Raufman, Jean Pierre.

In: American Journal of Physiology - Cell Physiology, Vol. 296, No. 2, 01.02.2009.

Research output: Contribution to journalReview article

Shah, Nirish ; Khurana, Sandeep ; Cheng, Kunrong ; Raufman, Jean Pierre. / Muscarinic receptors and ligands in cancer. In: American Journal of Physiology - Cell Physiology. 2009 ; Vol. 296, No. 2.
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