MuSK: A kinase critical for the formation and maintenance of the neuromuscular junction

Arnab Barik, Wen Cheng Xiong, Lin Mei

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Muscle-specific kinase (MuSK) is a RTK that is specifically expressed in skeletal muscle fibers and critical for the formation and maintenance of the neuromuscular junction (NMJ), a peripheral synapse formed between motoneurons and muscle fibers (1, 2). The acetylcholine receptors (AChRs) are concentrated at the crest of junctional folds on muscle fibers, critical for muscle contraction. Impaired NMJ formation or function in flicts muscular dystrophy. Being large and accessible, this peripheral synapse has served as a classic model of synapse function and synaptogenesis and has contributed a great deal to the understanding of molecular mechanisms of synapse formation in the brain. In this chapter, we will review the structures of MuSK in various vertebrates, its role in NMJ formation and maintenance, possible pathways that have been suggested by recent studies, and how MuSK may be a target in muscular dystrophy.

Original languageEnglish (US)
Title of host publicationNeuromethods
PublisherHumana Press Inc.
Pages203-217
Number of pages15
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Publication series

NameNeuromethods
Volume68
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Fingerprint

Neuromuscular Junction
Muscle
Phosphotransferases
Synapses
Maintenance
Muscles
Muscular Dystrophies
Fibers
Skeletal Muscle Fibers
Motor Neurons
Cholinergic Receptors
Muscle Contraction
Vertebrates
Brain

Keywords

  • AChR Pre-patterning
  • Agrin hypothesis
  • Juxtamembrane domain
  • Lrp4
  • MASC
  • Neuromuscular junction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

Cite this

Barik, A., Xiong, W. C., & Mei, L. (2012). MuSK: A kinase critical for the formation and maintenance of the neuromuscular junction. In Neuromethods (pp. 203-217). (Neuromethods; Vol. 68). Humana Press Inc.. https://doi.org/10.1007/978-1-61779-824-5_11

MuSK : A kinase critical for the formation and maintenance of the neuromuscular junction. / Barik, Arnab; Xiong, Wen Cheng; Mei, Lin.

Neuromethods. Humana Press Inc., 2012. p. 203-217 (Neuromethods; Vol. 68).

Research output: Chapter in Book/Report/Conference proceedingChapter

Barik, A, Xiong, WC & Mei, L 2012, MuSK: A kinase critical for the formation and maintenance of the neuromuscular junction. in Neuromethods. Neuromethods, vol. 68, Humana Press Inc., pp. 203-217. https://doi.org/10.1007/978-1-61779-824-5_11
Barik A, Xiong WC, Mei L. MuSK: A kinase critical for the formation and maintenance of the neuromuscular junction. In Neuromethods. Humana Press Inc. 2012. p. 203-217. (Neuromethods). https://doi.org/10.1007/978-1-61779-824-5_11
Barik, Arnab ; Xiong, Wen Cheng ; Mei, Lin. / MuSK : A kinase critical for the formation and maintenance of the neuromuscular junction. Neuromethods. Humana Press Inc., 2012. pp. 203-217 (Neuromethods).
@inbook{a91f948b134e4747bfa15a75545e21ef,
title = "MuSK: A kinase critical for the formation and maintenance of the neuromuscular junction",
abstract = "Muscle-specific kinase (MuSK) is a RTK that is specifically expressed in skeletal muscle fibers and critical for the formation and maintenance of the neuromuscular junction (NMJ), a peripheral synapse formed between motoneurons and muscle fibers (1, 2). The acetylcholine receptors (AChRs) are concentrated at the crest of junctional folds on muscle fibers, critical for muscle contraction. Impaired NMJ formation or function in flicts muscular dystrophy. Being large and accessible, this peripheral synapse has served as a classic model of synapse function and synaptogenesis and has contributed a great deal to the understanding of molecular mechanisms of synapse formation in the brain. In this chapter, we will review the structures of MuSK in various vertebrates, its role in NMJ formation and maintenance, possible pathways that have been suggested by recent studies, and how MuSK may be a target in muscular dystrophy.",
keywords = "AChR Pre-patterning, Agrin hypothesis, Juxtamembrane domain, Lrp4, MASC, Neuromuscular junction",
author = "Arnab Barik and Xiong, {Wen Cheng} and Lin Mei",
year = "2012",
month = "1",
day = "1",
doi = "10.1007/978-1-61779-824-5_11",
language = "English (US)",
series = "Neuromethods",
publisher = "Humana Press Inc.",
pages = "203--217",
booktitle = "Neuromethods",

}

TY - CHAP

T1 - MuSK

T2 - A kinase critical for the formation and maintenance of the neuromuscular junction

AU - Barik, Arnab

AU - Xiong, Wen Cheng

AU - Mei, Lin

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Muscle-specific kinase (MuSK) is a RTK that is specifically expressed in skeletal muscle fibers and critical for the formation and maintenance of the neuromuscular junction (NMJ), a peripheral synapse formed between motoneurons and muscle fibers (1, 2). The acetylcholine receptors (AChRs) are concentrated at the crest of junctional folds on muscle fibers, critical for muscle contraction. Impaired NMJ formation or function in flicts muscular dystrophy. Being large and accessible, this peripheral synapse has served as a classic model of synapse function and synaptogenesis and has contributed a great deal to the understanding of molecular mechanisms of synapse formation in the brain. In this chapter, we will review the structures of MuSK in various vertebrates, its role in NMJ formation and maintenance, possible pathways that have been suggested by recent studies, and how MuSK may be a target in muscular dystrophy.

AB - Muscle-specific kinase (MuSK) is a RTK that is specifically expressed in skeletal muscle fibers and critical for the formation and maintenance of the neuromuscular junction (NMJ), a peripheral synapse formed between motoneurons and muscle fibers (1, 2). The acetylcholine receptors (AChRs) are concentrated at the crest of junctional folds on muscle fibers, critical for muscle contraction. Impaired NMJ formation or function in flicts muscular dystrophy. Being large and accessible, this peripheral synapse has served as a classic model of synapse function and synaptogenesis and has contributed a great deal to the understanding of molecular mechanisms of synapse formation in the brain. In this chapter, we will review the structures of MuSK in various vertebrates, its role in NMJ formation and maintenance, possible pathways that have been suggested by recent studies, and how MuSK may be a target in muscular dystrophy.

KW - AChR Pre-patterning

KW - Agrin hypothesis

KW - Juxtamembrane domain

KW - Lrp4

KW - MASC

KW - Neuromuscular junction

UR - http://www.scopus.com/inward/record.url?scp=84979247252&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979247252&partnerID=8YFLogxK

U2 - 10.1007/978-1-61779-824-5_11

DO - 10.1007/978-1-61779-824-5_11

M3 - Chapter

AN - SCOPUS:84979247252

T3 - Neuromethods

SP - 203

EP - 217

BT - Neuromethods

PB - Humana Press Inc.

ER -