TY - JOUR
T1 - Mutagenesis and the three R's in yeast
AU - Abdulovic, Amy
AU - Kim, Nayun
AU - Jinks-Robertson, Sue
N1 - Funding Information:
We apologize to our colleagues whose work was not cited because of space constraints. We also thank Gray Crouse, Tom Petes, Allison Rattray and Wolfram Siede for providing helpful comments on the manuscript, and past and present members of the laboratory for the discussions that led to the development of ideas presented in this review. Research in S.J.-R.'s laboratory is supported by NIH grants GM038464 and GM064769. A.L.A. and N.K. are partially supported by the Emory University Graduate Division of Biological and Biomedical Sciences and by the University Research Committee, respectively.
PY - 2006/4/8
Y1 - 2006/4/8
N2 - Mutagenesis is a prerequisite for evolution and also is an important contributor to human diseases. Most mutations in actively dividing cells originate during DNA replication as errors introduced when copying an undamaged DNA template or during the bypass of DNA lesions. In addition, mutations can be introduced during the repair of DNA double-strand breaks by either homologous recombination or non-homologous end-joining pathways. Finally, although generally considered to be a very high-fidelity process, the excision repair of DNA damage may be an important contributor to mutagenesis in non-dividing cells. In this review, we will discuss the well-known contributions of DNA replication to mutagenesis in Saccharomyces cerevisiae, as well as the less-appreciated contributions of recombination and repair to mutagenesis in this organism.
AB - Mutagenesis is a prerequisite for evolution and also is an important contributor to human diseases. Most mutations in actively dividing cells originate during DNA replication as errors introduced when copying an undamaged DNA template or during the bypass of DNA lesions. In addition, mutations can be introduced during the repair of DNA double-strand breaks by either homologous recombination or non-homologous end-joining pathways. Finally, although generally considered to be a very high-fidelity process, the excision repair of DNA damage may be an important contributor to mutagenesis in non-dividing cells. In this review, we will discuss the well-known contributions of DNA replication to mutagenesis in Saccharomyces cerevisiae, as well as the less-appreciated contributions of recombination and repair to mutagenesis in this organism.
KW - Mutagenesis
KW - Recombination
KW - Repair
KW - Replication
KW - Translesion synthesis
KW - Yeast
UR - http://www.scopus.com/inward/record.url?scp=33645359197&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645359197&partnerID=8YFLogxK
U2 - 10.1016/j.dnarep.2005.11.006
DO - 10.1016/j.dnarep.2005.11.006
M3 - Review article
C2 - 16412705
AN - SCOPUS:33645359197
SN - 1568-7864
VL - 5
SP - 409
EP - 421
JO - DNA Repair
JF - DNA Repair
IS - 4
ER -
