Abstract
Follicle-stimulating hormone (FSH), a dimeric glycoprotein synthesized in the anterior pituitary gland, is important for the production of sex steroids and gametes. FSH-beta (FSHβ) and FSH receptor (FSHR) knockout mice display impaired ovarian follicular development and infertility in females and small testes, oligospermia, and fertility in males. Humans with FSHβ gene mutations tend to have a more severe phenotype than those with FSHR gene mutations, although infertility and varying degrees of impaired sex steroid production occur in both types of mutations. Data from human and mouse mutations in the FSHβ and FSHR genes suggest that FSH is necessary for normal pubertal development and fertility in males and females.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5-10 |
| Number of pages | 6 |
| Journal | Seminars in Reproductive Medicine |
| Volume | 18 |
| Issue number | 1 |
| State | Published - Dec 1 2000 |
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Keywords
- Follicle-stimulating hormone
- FSH receptor
- FSHβ gene
- FSHR gene
- Isolated FSH deficiency
ASJC Scopus subject areas
- Endocrinology
- Physiology
- Obstetrics and Gynecology
- Reproductive Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Mutations in the follicle-stimulating hormone-beta (FSHβ) and FSH receptor genes in mice and humans. / Layman, Lawrence C.
In: Seminars in Reproductive Medicine, Vol. 18, No. 1, 01.12.2000, p. 5-10.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Mutations in the follicle-stimulating hormone-beta (FSHβ) and FSH receptor genes in mice and humans
AU - Layman, Lawrence C
PY - 2000/12/1
Y1 - 2000/12/1
N2 - Follicle-stimulating hormone (FSH), a dimeric glycoprotein synthesized in the anterior pituitary gland, is important for the production of sex steroids and gametes. FSH-beta (FSHβ) and FSH receptor (FSHR) knockout mice display impaired ovarian follicular development and infertility in females and small testes, oligospermia, and fertility in males. Humans with FSHβ gene mutations tend to have a more severe phenotype than those with FSHR gene mutations, although infertility and varying degrees of impaired sex steroid production occur in both types of mutations. Data from human and mouse mutations in the FSHβ and FSHR genes suggest that FSH is necessary for normal pubertal development and fertility in males and females.
AB - Follicle-stimulating hormone (FSH), a dimeric glycoprotein synthesized in the anterior pituitary gland, is important for the production of sex steroids and gametes. FSH-beta (FSHβ) and FSH receptor (FSHR) knockout mice display impaired ovarian follicular development and infertility in females and small testes, oligospermia, and fertility in males. Humans with FSHβ gene mutations tend to have a more severe phenotype than those with FSHR gene mutations, although infertility and varying degrees of impaired sex steroid production occur in both types of mutations. Data from human and mouse mutations in the FSHβ and FSHR genes suggest that FSH is necessary for normal pubertal development and fertility in males and females.
KW - Follicle-stimulating hormone
KW - FSH receptor
KW - FSHβ gene
KW - FSHR gene
KW - Isolated FSH deficiency
UR - http://www.scopus.com/inward/record.url?scp=0034475085&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034475085&partnerID=8YFLogxK
M3 - Review article
C2 - 11299519
AN - SCOPUS:0034475085
VL - 18
SP - 5
EP - 10
JO - Seminars in Reproductive Medicine
JF - Seminars in Reproductive Medicine
SN - 1526-8004
IS - 1
ER -