Myc and a Cdk2 senescence switch

Jan Van Riggelen, Dean W. Felsher

Research output: Contribution to journalArticle

22 Scopus citations


Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.

Original languageEnglish (US)
Pages (from-to)7-9
Number of pages3
JournalNature Cell Biology
Issue number1
Publication statusPublished - Jan 1 2010
Externally publishedYes


ASJC Scopus subject areas

  • Cell Biology

Cite this

Van Riggelen, J., & Felsher, D. W. (2010). Myc and a Cdk2 senescence switch. Nature Cell Biology, 12(1), 7-9.