Myc and a Cdk2 senescence switch

Jan Van Riggelen, Dean W. Felsher

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.

Original languageEnglish (US)
Pages (from-to)7-9
Number of pages3
JournalNature Cell Biology
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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