Myc and a Cdk2 senescence switch

Jan Van Riggelen, Dean W. Felsher

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.

Original languageEnglish (US)
Pages (from-to)7-9
Number of pages3
JournalNature Cell Biology
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

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Carcinogenesis
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Cell Biology

Cite this

Van Riggelen, J., & Felsher, D. W. (2010). Myc and a Cdk2 senescence switch. Nature Cell Biology, 12(1), 7-9. https://doi.org/10.1038/ncb0110-7

Myc and a Cdk2 senescence switch. / Van Riggelen, Jan; Felsher, Dean W.

In: Nature Cell Biology, Vol. 12, No. 1, 01.01.2010, p. 7-9.

Research output: Contribution to journalArticle

Van Riggelen, J & Felsher, DW 2010, 'Myc and a Cdk2 senescence switch', Nature Cell Biology, vol. 12, no. 1, pp. 7-9. https://doi.org/10.1038/ncb0110-7
Van Riggelen, Jan ; Felsher, Dean W. / Myc and a Cdk2 senescence switch. In: Nature Cell Biology. 2010 ; Vol. 12, No. 1. pp. 7-9.
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