Myc and a Cdk2 senescence switch

Jan Van Riggelen, Dean W. Felsher

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.

Original languageEnglish (US)
Pages (from-to)7-9
Number of pages3
JournalNature Cell Biology
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'Myc and a Cdk2 senescence switch'. Together they form a unique fingerprint.

  • Cite this

    Van Riggelen, J., & Felsher, D. W. (2010). Myc and a Cdk2 senescence switch. Nature Cell Biology, 12(1), 7-9. https://doi.org/10.1038/ncb0110-7