Myelin Gangliosides in Vertebrates

Frederick B. Cochran, Robert K Yu, Robert W. Ledeen

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Abstract: A phylogenetic survey of brain myelin ganglioside patterns and concentrations has been carried out on 16 vertebrate species. Gangliosides were isolated from purified myelin and found to vary in concentration from 25 μg of sialic acid per 100 mg of myeh for goldfish to a value of 395 for turkey. The latter species had approximately equivalent amounts of GM1 and GM4 as the two major gangliosides. The 11 mammals studied all had GM1 as the major ganglioside, with variable amounts of GM4; rhesus monkey and human had 20‐25% GM4, whereas the others had less than 10%. Amphibia and fish myelin contained the least total ganglioside, with patterns that showed relatively little GM1 and no detectable GM4. Alligator myelin was unique in having a total concentration as high as the avian species, but a pattern with predominantly diand trisialo gangliosides.

Original languageEnglish (US)
Pages (from-to)773-779
Number of pages7
JournalJournal of Neurochemistry
Volume39
Issue number3
DOIs
StatePublished - Jan 1 1982

Fingerprint

Gangliosides
Myelin Sheath
Vertebrates
Alligators and Crocodiles
Goldfish
Mammals
Amphibians
N-Acetylneuraminic Acid
Macaca mulatta
Fish
Brain
Fishes

Keywords

  • Central nervous system
  • Ganglioside G
  • Ganglioside G
  • Gangliosides
  • Myelin
  • Myelin proteins
  • Species variation

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Myelin Gangliosides in Vertebrates. / Cochran, Frederick B.; Yu, Robert K; Ledeen, Robert W.

In: Journal of Neurochemistry, Vol. 39, No. 3, 01.01.1982, p. 773-779.

Research output: Contribution to journalArticle

Cochran, Frederick B. ; Yu, Robert K ; Ledeen, Robert W. / Myelin Gangliosides in Vertebrates. In: Journal of Neurochemistry. 1982 ; Vol. 39, No. 3. pp. 773-779.
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