Myelinoclastic diffuse sclerosis presenting as a mass lesion in a child with turner’s syndrome

Joseph B. Stachniak, J. Parker Mickle, Thomas Ellis, Ronald Quisling, Amyn M. Rojiani

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A rare case of myelinoclastic diffuse sclerosis (MDS), occasionally referred to as Schilder’s disease, is reported in a child with Turner’s syndrome. The child originally presented with a 3-week history of nausea, vomiting and frontal headaches. Magnetic resonance imaging showed a large, contrast-enhancing, right frontal lobe mass which was ultimately resected uneventfully. Complete laboratory investigations and pathological evaluation of the resected specimen verified the case to be MDS. The clinical presentation, laboratory evaluation, imaging characteristics and diagnosis are discussed in this review of the disease. The importance of including demyelinating diseases in the differential diagnosis for newly discovered mass lesions in the pediatric population is underscored by this case.

Original languageEnglish (US)
Pages (from-to)266-269
Number of pages4
JournalPediatric Neurosurgery
Volume22
Issue number5
DOIs
Publication statusPublished - Jan 1 1995
Externally publishedYes

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Keywords

  • Myelinoclastic diffuse sclerosis
  • Schilder’s disease
  • Turner’s syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

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