Myeloid cell signatures in tumor microenvironment predicts therapeutic response in cancer

Bhagelu R. Achyut, Ali S. Arbab

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Tumor microenvironment (TME) consists of several immune and nonimmune cell populations including tumor cells. For many decades, experimental studies have depicted profound contribution of TME toward cancer progression and metastasis development. Several therapeutic strategies have been tested against TME through preclinical studies and clinical trials. Unfortunately, most of them have shown transient effect, and have largely failed due to aggressive tumor growth and without improving survival. Solid tumors are known to have a strong myeloid component (eg, tumor-associated macrophages) in tumor development. Recent data suggest that therapeutic responses in tumor are characterized by alterations in immune cell signatures, including tumor-associated myeloid cells. Polarized tumor-associated myeloid cells (M1–M2) are critical in impairing therapeutic effect and promoting tumor growth. The present review is intended to compile all the literatures related to the emerging contribution of different populations of myeloid cells in the development of tumor and therapeutic failures. Finally, we have discussed targeting of myeloid cell populations as a combination therapy with chemo-, targeted-, or radiation therapies.

Original languageEnglish (US)
Pages (from-to)1047-1055
Number of pages9
JournalOncoTargets and Therapy
Volume9
DOIs
StatePublished - Mar 1 2016

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Keywords

  • Antiangiogenic therapy
  • Macrophage polarization
  • Myeloid-derived suppressor cells
  • Radiation
  • Therapies
  • Tumor microenvironment
  • Tumor-associated macrophage

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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