Myeloid Derived Suppressor Cells: Fuel the Fire

B R Achyut, Ali S Arbab

Research output: Contribution to journalArticle

Abstract

Low oxygen tension, hypoxia, is a characteristic of many tumors and associated with the poor prognosis. Hypoxia invites bone marrow derived cells (BMDCs) from bone marrow to the site of tumor. These recruited CXCR4+ BMDCs provide favorable environment for the tumor growth by acquiring pro-angiogenic phenotype such as CD45+VEGFR2+ Endothelial Progenitor Cells (EPC), or CD45+Tie2+ myeloid cells. CD11b+CD13+ myeloid population of the BMDCs modulate tumor progression. These myeloid populations retain immunosuppressive characteristics, for example, myeloid derived suppressor cells (MDSCs), and regulates immune- suppression by inhibiting cytotoxic T cell function. In addition, MDSCs were observed at the premetastatic niche of the distant organs in other tumors. Protumorigenic and prometastatic role of the myeloid cells provides a basis for therapeutic targeting of immunosuppression and thus inhibiting tumor development and metastasis.

Original languageEnglish (US)
Pages (from-to)e123
JournalPesticide Biochemistry and Physiology
Volume3
Issue number3
DOIs
StatePublished - Aug 2014
Externally publishedYes

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suppressor cells
bone marrow
neoplasms
Bone Marrow Cells
Neoplasms
Myeloid Cells
cells
hypoxia
immunosuppressive agents
immunosuppression
Immunosuppressive Agents
metastasis
Immunosuppression
Population
endothelial cells
prognosis
stem cells
Myeloid-Derived Suppressor Cells
niches
T-lymphocytes

Cite this

Myeloid Derived Suppressor Cells : Fuel the Fire. / Achyut, B R; Arbab, Ali S.

In: Pesticide Biochemistry and Physiology, Vol. 3, No. 3, 08.2014, p. e123.

Research output: Contribution to journalArticle

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