Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats

Stephen M. Silver, Barbara M. Schroeder, Richard H. Sterns, Amyn Mohammed Rojiani

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

When chronic hyponatremia is rapidly corrected, reaccumulation of brain organic osmolytes is delayed and brain cell shrinkage occurs, leading to the osmotic demyelination syndrome (ODS). We hypothesized that treatment with myoinositol, a major organic osmolyte, could prevent ODS. Severe hyponatremia was induced in adult male rats by administration of arginine vasopressin and intravenous infusion of dextrose and water. Sixty-four hours after induction of hyponatremia, all animals underwent rapid correction of hyponatremia with infusion of hypertonic saline over 4 hours, increasing the serum sodium from 105 to 135 mM; half of the animals were also given myoinositol intravenously beginning 20 minutes before correction and continuing for 28 hours. Serum sodium concentrations were equivalent in both groups at all time points. At 7 days, 7 of 8 animals that received myoinositol survived compared with one of the 9 control animals (p < 0.01). In a second study, sodium was reduced to 106 mM over 64 hours in 24 animals and then corrected by 20 mM over 4 hours with concomitant loading and infusion of either mannitol (control) or myoinositol. Animals were killed 96 hours after correction of hyponatremia was begun. Myoinositol-treated animals had significantly fewer demyelinating lesions than mannitol (2.25 ± 1.1 versus 6.42 ± 1.4 lesions/brain, p < 0.03). We conclude that myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalJournal of Neuropathology and Experimental Neurology
Volume65
Issue number1
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

Fingerprint

Hyponatremia
Inositol
Sodium
Demyelinating Diseases
Mannitol
Brain
Arginine Vasopressin
Serum
Intravenous Infusions
Glucose
Water

Keywords

  • Brain osmolarity
  • Central pontine myelinolysis
  • Demyelinating diseases
  • Hyponatremia
  • Myoinositol

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. / Silver, Stephen M.; Schroeder, Barbara M.; Sterns, Richard H.; Rojiani, Amyn Mohammed.

In: Journal of Neuropathology and Experimental Neurology, Vol. 65, No. 1, 01.01.2006, p. 37-44.

Research output: Contribution to journalArticle

@article{c3f10d21d6ce45eebe8ea6553b8e05cc,
title = "Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats",
abstract = "When chronic hyponatremia is rapidly corrected, reaccumulation of brain organic osmolytes is delayed and brain cell shrinkage occurs, leading to the osmotic demyelination syndrome (ODS). We hypothesized that treatment with myoinositol, a major organic osmolyte, could prevent ODS. Severe hyponatremia was induced in adult male rats by administration of arginine vasopressin and intravenous infusion of dextrose and water. Sixty-four hours after induction of hyponatremia, all animals underwent rapid correction of hyponatremia with infusion of hypertonic saline over 4 hours, increasing the serum sodium from 105 to 135 mM; half of the animals were also given myoinositol intravenously beginning 20 minutes before correction and continuing for 28 hours. Serum sodium concentrations were equivalent in both groups at all time points. At 7 days, 7 of 8 animals that received myoinositol survived compared with one of the 9 control animals (p < 0.01). In a second study, sodium was reduced to 106 mM over 64 hours in 24 animals and then corrected by 20 mM over 4 hours with concomitant loading and infusion of either mannitol (control) or myoinositol. Animals were killed 96 hours after correction of hyponatremia was begun. Myoinositol-treated animals had significantly fewer demyelinating lesions than mannitol (2.25 ± 1.1 versus 6.42 ± 1.4 lesions/brain, p < 0.03). We conclude that myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats.",
keywords = "Brain osmolarity, Central pontine myelinolysis, Demyelinating diseases, Hyponatremia, Myoinositol",
author = "Silver, {Stephen M.} and Schroeder, {Barbara M.} and Sterns, {Richard H.} and Rojiani, {Amyn Mohammed}",
year = "2006",
month = "1",
day = "1",
doi = "10.1097/01.jnen.0000195938.02292.39",
language = "English (US)",
volume = "65",
pages = "37--44",
journal = "American Journal of Psychotherapy",
issn = "0002-9564",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats

AU - Silver, Stephen M.

AU - Schroeder, Barbara M.

AU - Sterns, Richard H.

AU - Rojiani, Amyn Mohammed

PY - 2006/1/1

Y1 - 2006/1/1

N2 - When chronic hyponatremia is rapidly corrected, reaccumulation of brain organic osmolytes is delayed and brain cell shrinkage occurs, leading to the osmotic demyelination syndrome (ODS). We hypothesized that treatment with myoinositol, a major organic osmolyte, could prevent ODS. Severe hyponatremia was induced in adult male rats by administration of arginine vasopressin and intravenous infusion of dextrose and water. Sixty-four hours after induction of hyponatremia, all animals underwent rapid correction of hyponatremia with infusion of hypertonic saline over 4 hours, increasing the serum sodium from 105 to 135 mM; half of the animals were also given myoinositol intravenously beginning 20 minutes before correction and continuing for 28 hours. Serum sodium concentrations were equivalent in both groups at all time points. At 7 days, 7 of 8 animals that received myoinositol survived compared with one of the 9 control animals (p < 0.01). In a second study, sodium was reduced to 106 mM over 64 hours in 24 animals and then corrected by 20 mM over 4 hours with concomitant loading and infusion of either mannitol (control) or myoinositol. Animals were killed 96 hours after correction of hyponatremia was begun. Myoinositol-treated animals had significantly fewer demyelinating lesions than mannitol (2.25 ± 1.1 versus 6.42 ± 1.4 lesions/brain, p < 0.03). We conclude that myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats.

AB - When chronic hyponatremia is rapidly corrected, reaccumulation of brain organic osmolytes is delayed and brain cell shrinkage occurs, leading to the osmotic demyelination syndrome (ODS). We hypothesized that treatment with myoinositol, a major organic osmolyte, could prevent ODS. Severe hyponatremia was induced in adult male rats by administration of arginine vasopressin and intravenous infusion of dextrose and water. Sixty-four hours after induction of hyponatremia, all animals underwent rapid correction of hyponatremia with infusion of hypertonic saline over 4 hours, increasing the serum sodium from 105 to 135 mM; half of the animals were also given myoinositol intravenously beginning 20 minutes before correction and continuing for 28 hours. Serum sodium concentrations were equivalent in both groups at all time points. At 7 days, 7 of 8 animals that received myoinositol survived compared with one of the 9 control animals (p < 0.01). In a second study, sodium was reduced to 106 mM over 64 hours in 24 animals and then corrected by 20 mM over 4 hours with concomitant loading and infusion of either mannitol (control) or myoinositol. Animals were killed 96 hours after correction of hyponatremia was begun. Myoinositol-treated animals had significantly fewer demyelinating lesions than mannitol (2.25 ± 1.1 versus 6.42 ± 1.4 lesions/brain, p < 0.03). We conclude that myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats.

KW - Brain osmolarity

KW - Central pontine myelinolysis

KW - Demyelinating diseases

KW - Hyponatremia

KW - Myoinositol

UR - http://www.scopus.com/inward/record.url?scp=33644905324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644905324&partnerID=8YFLogxK

U2 - 10.1097/01.jnen.0000195938.02292.39

DO - 10.1097/01.jnen.0000195938.02292.39

M3 - Article

VL - 65

SP - 37

EP - 44

JO - American Journal of Psychotherapy

JF - American Journal of Psychotherapy

SN - 0002-9564

IS - 1

ER -