NADH/NADPH oxidase and vascular function

Kathy K. Griendling, Masuko Fukai

Research output: Contribution to journalReview article

80 Citations (Scopus)

Abstract

The vascular NADH/NADPH oxidase has been shown to be the major source of superoxide in the vessel wall. Recent work has provided insight into its structure and activity in vascular cells. This enzyme is involved in both vascular smooth muscle hypertrophy and in some forms of impaired endothelium- dependent relaxation. Because oxidative stress in general participates in the pathogenesis of hypertension and atherosclerosis, the enzymes that produce reactive oxygen species may be important determinants of the course of vascular disease.

Original languageEnglish (US)
Pages (from-to)301-307
Number of pages7
JournalTrends in Cardiovascular Medicine
Volume7
Issue number8
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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NADPH Oxidase
Blood Vessels
Enzymes
Vascular Diseases
Vascular Smooth Muscle
Superoxides
Hypertrophy
Endothelium
Reactive Oxygen Species
Atherosclerosis
Oxidative Stress
Hypertension
NADH oxidase

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

NADH/NADPH oxidase and vascular function. / Griendling, Kathy K.; Fukai, Masuko.

In: Trends in Cardiovascular Medicine, Vol. 7, No. 8, 01.01.1997, p. 301-307.

Research output: Contribution to journalReview article

Griendling, Kathy K. ; Fukai, Masuko. / NADH/NADPH oxidase and vascular function. In: Trends in Cardiovascular Medicine. 1997 ; Vol. 7, No. 8. pp. 301-307.
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