Na/K-ATPase mimetic pNaKtide peptide inhibits the growth of human cancer cells

Zhichuan Li, Zhongbing Zhang, Joe X. Xie, Xin Li, Jiang Tian, Ting Cai, Hongjuan Cui, Hanfei Ding, Joseph I. Shapiro, Zijian Xie

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Cells contain a large pool of nonpumping Na/K-ATPase that participates in signal transduction. Here, we show that the expression of α1 Na/K-ATPase is significantly reduced in human prostate carcinoma as well as in several human cancer cell lines. This down-regulation impairs the ability of Na/KATPase to regulate Src-related signaling processes. A supplement of pNaKtide, a peptide derived from α1 Na/K-ATPase, reduces the activities of Src and Src effectors. Consequently, these treatments stimulate apoptosis and inhibit growth in cultures of human cancer cells. Moreover, administration of pNaKtide inhibits angiogenesis and growth of tumor xenograft. Thus, the new findings demonstrate the in vivo effectiveness of pNaKtide and suggest that the defect in Na/K-ATPase-mediated signal transduction may be targeted for developing new anticancer therapeutics.

Original languageEnglish (US)
Pages (from-to)32394-32403
Number of pages10
JournalJournal of Biological Chemistry
Volume286
Issue number37
DOIs
StatePublished - Sep 16 2011

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Li, Z., Zhang, Z., Xie, J. X., Li, X., Tian, J., Cai, T., Cui, H., Ding, H., Shapiro, J. I., & Xie, Z. (2011). Na/K-ATPase mimetic pNaKtide peptide inhibits the growth of human cancer cells. Journal of Biological Chemistry, 286(37), 32394-32403. https://doi.org/10.1074/jbc.M110.207597