Naloxone prevents increased vascular sensitivity in goldblatt hypertensive rats

Min Chen, R. Clinton Webb, Richard L. Malvin

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

These experiments were designed to determine if the opiate antagonist naloxone affects vascular sensitivity in 2K-1C hypertensive rats. Group 1 was 2K-1C hypertensive rats. Group 2 was 2K-1C rats given a naloxone infusion (100 μg/h) for 14 days. Group 3 received naloxone without clipping. Group 4 was untreated rats. At day 14 following clipping, systolic blood pressure was increased significantly in the 2K-1C rats. Those infused with naloxone showed a significant attenuation of the increase in blood pressure. Vascular responses to norepinephrine and KCI in the aortae from all groups were tested. Strips from untreated, 2K-1C rats were more sensitive to the contractile effects of norepinephrine than those from naloxonetreated, 2K-1C rats, and from both groups of normotensive rats. Contractile responsiveness to depolarizing concentrations of KCI were not different among the four groups. These data demonstrate that naloxone attenuates the development of renal hypertension and prevents the increase in vascular responsiveness to norepinephrine.

Original languageEnglish (US)
Pages (from-to)1361-1376
Number of pages16
JournalClinical and experimental hypertension
VolumeA12
Issue number8
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Keywords

  • Naloxone
  • Renal Hypertension
  • Vascular Sensitivity

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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