Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment

Hongmin Chen, Geoffrey D. Wang, Yen Jun Chuang, Zipeng Zhen, Xiaoyuan Chen, Paul Williams Biddinger, Zhonglin Hao, Feng Liu, Baozhong Shen, Zhengwei Pan, Jin Xie

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

Original languageEnglish (US)
Pages (from-to)2249-2256
Number of pages8
JournalNano Letters
Volume15
Issue number4
DOIs
StatePublished - Apr 8 2015

Fingerprint

Photodynamic therapy
Oncology
therapy
cancer
X rays
Photosensitizing Agents
Photosensitizers
x rays
Photons
Nanosystems
photons
shrinkage
Silicon Dioxide
Tumors
tumors
penetration
Silica
Irradiation
silicon dioxide
coatings

Keywords

  • X-PDT
  • cancer treatment
  • nanomedicine
  • nanoscintillator
  • radioluminescence nanophosphors
  • singlet oxygen

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment. / Chen, Hongmin; Wang, Geoffrey D.; Chuang, Yen Jun; Zhen, Zipeng; Chen, Xiaoyuan; Biddinger, Paul Williams; Hao, Zhonglin; Liu, Feng; Shen, Baozhong; Pan, Zhengwei; Xie, Jin.

In: Nano Letters, Vol. 15, No. 4, 08.04.2015, p. 2249-2256.

Research output: Contribution to journalArticle

Chen, H, Wang, GD, Chuang, YJ, Zhen, Z, Chen, X, Biddinger, PW, Hao, Z, Liu, F, Shen, B, Pan, Z & Xie, J 2015, 'Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment', Nano Letters, vol. 15, no. 4, pp. 2249-2256. https://doi.org/10.1021/nl504044p
Chen, Hongmin ; Wang, Geoffrey D. ; Chuang, Yen Jun ; Zhen, Zipeng ; Chen, Xiaoyuan ; Biddinger, Paul Williams ; Hao, Zhonglin ; Liu, Feng ; Shen, Baozhong ; Pan, Zhengwei ; Xie, Jin. / Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment. In: Nano Letters. 2015 ; Vol. 15, No. 4. pp. 2249-2256.
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