Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment

Hongmin Chen, Geoffrey D. Wang, Yen Jun Chuang, Zipeng Zhen, Xiaoyuan Chen, Paul Williams Biddinger, Zhonglin Hao, Feng Liu, Baozhong Shen, Zhengwei Pan, Jin Xie

Research output: Contribution to journalArticle

155 Scopus citations

Abstract

Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

Original languageEnglish (US)
Pages (from-to)2249-2256
Number of pages8
JournalNano Letters
Volume15
Issue number4
DOIs
StatePublished - Apr 8 2015

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Keywords

  • X-PDT
  • cancer treatment
  • nanomedicine
  • nanoscintillator
  • radioluminescence nanophosphors
  • singlet oxygen

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Chen, H., Wang, G. D., Chuang, Y. J., Zhen, Z., Chen, X., Biddinger, P. W., Hao, Z., Liu, F., Shen, B., Pan, Z., & Xie, J. (2015). Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in Vivo Cancer Treatment. Nano Letters, 15(4), 2249-2256. https://doi.org/10.1021/nl504044p