Abstract
The natural history of chronic myelogenous leukaemia has changed in recent years, partly as a result of earlier diagnosis but mostly as a consequence of the availability of effective therapies that have the potential to eradicate the Philadelphia-positive clone. The prognostic models designed in the pre-interferon-α (IFN-α) era based on clinical characteristics of the disease are still useful in identifying different risk groups after treatment with IFN-α, but achieving a cytogenetic response with IFN-α is now the most important prognostic factor for survival. The significance of other molecular and biological variables remains to be determined.
Original language | English (US) |
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Pages (from-to) | 277-290 |
Number of pages | 14 |
Journal | Bailliere's Clinical Haematology |
Volume | 10 |
Issue number | 2 |
DOIs | |
State | Published - 1997 |
Externally published | Yes |
Keywords
- Chronic myoloid leukaemia
- Cytogenetic response
- Interferon
- Prognosis
- Stage
ASJC Scopus subject areas
- Hematology