Naturally occurring Nrf2 activators

Potential in treatment of liver injury

Ravirajsinh N. Jadeja, Kapil K. Upadhyay, Ranjitsinh V. Devkar, Sandeep Khurana

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative stress frequently triggers antioxidant response by activating nuclear erythroid 2-related factor 2 (Nrf2), a transcription factor, which upregulates various cytoprotective genes. Thus, Nrf2 is considered a potential therapeutic target to halt liver injury. Several studies indicate that activation of Nrf2 signaling pathway ameliorates liver injury.The hepatoprotective potential of naturally occurring compounds has been investigated in various models of liver injuries. In this review, we comprehensively appraise various phytochemicals that have been assessed for their potential to halt acute and chronic liver injury by enhancing the activation of Nrf2 and have the potential for use in humans.

Original languageEnglish (US)
Article number3453926
JournalOxidative Medicine and Cellular Longevity
Volume2016
DOIs
StatePublished - Jan 1 2016

Fingerprint

Liver
Wounds and Injuries
Oxidative stress
Oxidative Stress
Chemical activation
Phytochemicals
Hepatocytes
Transcription Factors
Up-Regulation
Antioxidants
Genes
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Cell Biology

Cite this

Naturally occurring Nrf2 activators : Potential in treatment of liver injury. / Jadeja, Ravirajsinh N.; Upadhyay, Kapil K.; Devkar, Ranjitsinh V.; Khurana, Sandeep.

In: Oxidative Medicine and Cellular Longevity, Vol. 2016, 3453926, 01.01.2016.

Research output: Contribution to journalReview article

Jadeja, Ravirajsinh N. ; Upadhyay, Kapil K. ; Devkar, Ranjitsinh V. ; Khurana, Sandeep. / Naturally occurring Nrf2 activators : Potential in treatment of liver injury. In: Oxidative Medicine and Cellular Longevity. 2016 ; Vol. 2016.
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