Naturally occurring Nrf2 activators: Potential in treatment of liver injury

Ravirajsinh N. Jadeja, Kapil K. Upadhyay, Ranjitsinh V. Devkar, Sandeep Khurana

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative stress frequently triggers antioxidant response by activating nuclear erythroid 2-related factor 2 (Nrf2), a transcription factor, which upregulates various cytoprotective genes. Thus, Nrf2 is considered a potential therapeutic target to halt liver injury. Several studies indicate that activation of Nrf2 signaling pathway ameliorates liver injury.The hepatoprotective potential of naturally occurring compounds has been investigated in various models of liver injuries. In this review, we comprehensively appraise various phytochemicals that have been assessed for their potential to halt acute and chronic liver injury by enhancing the activation of Nrf2 and have the potential for use in humans.

Original languageEnglish (US)
Article number3453926
JournalOxidative medicine and cellular longevity
Volume2016
DOIs
Publication statusPublished - Jan 1 2016

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ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Cell Biology

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