TY - JOUR
T1 - Naturally occurring Nrf2 activators
T2 - Potential in treatment of liver injury
AU - Jadeja, Ravirajsinh N.
AU - Upadhyay, Kapil K.
AU - Devkar, Ranjitsinh V.
AU - Khurana, Sandeep
N1 - Publisher Copyright:
© 2016 Ravirajsinh N. Jadeja et al.
PY - 2016
Y1 - 2016
N2 - Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative stress frequently triggers antioxidant response by activating nuclear erythroid 2-related factor 2 (Nrf2), a transcription factor, which upregulates various cytoprotective genes. Thus, Nrf2 is considered a potential therapeutic target to halt liver injury. Several studies indicate that activation of Nrf2 signaling pathway ameliorates liver injury.The hepatoprotective potential of naturally occurring compounds has been investigated in various models of liver injuries. In this review, we comprehensively appraise various phytochemicals that have been assessed for their potential to halt acute and chronic liver injury by enhancing the activation of Nrf2 and have the potential for use in humans.
AB - Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative stress frequently triggers antioxidant response by activating nuclear erythroid 2-related factor 2 (Nrf2), a transcription factor, which upregulates various cytoprotective genes. Thus, Nrf2 is considered a potential therapeutic target to halt liver injury. Several studies indicate that activation of Nrf2 signaling pathway ameliorates liver injury.The hepatoprotective potential of naturally occurring compounds has been investigated in various models of liver injuries. In this review, we comprehensively appraise various phytochemicals that have been assessed for their potential to halt acute and chronic liver injury by enhancing the activation of Nrf2 and have the potential for use in humans.
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U2 - 10.1155/2016/3453926
DO - 10.1155/2016/3453926
M3 - Review article
C2 - 28101296
AN - SCOPUS:85008883748
SN - 1942-0900
VL - 2016
JO - Oxidative medicine and cellular longevity
JF - Oxidative medicine and cellular longevity
M1 - 3453926
ER -