Neddylation and deneddylation in cardiac biology

Sridhar Kandala, Il-man Kim, Huabo Su

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Neddylation is a post-translational protein modification that conjugates a ubiquitin-like protein NEDD8 to target proteins. Similar to ubiquitination, neddylation is mediated by a cascade of three NEDD8 specific enzymes, an E1 activating enzyme, an E2 conjugating enzyme and one of the several E3 ligases. Neddylation is countered by the action of deneddylases via a process termed deneddylation. By altering the substrate’s conformation, stability, subcellular localization or binding affinity to DNA or proteins, neddylation regulates diverse cellular processes including the ubiquitin-proteasome system-mediated protein degradation, protein transcription, cell signaling etc. Dysregulation of neddylation has been linked to cancer, neurodegenerative disorders, and more recently, cardiac disease. Here we comprehensively overview the biochemistry, the proteome and the biological function of neddylation. We also summarize the recent progress in revealing the physiological and pathological role of neddylation and deneddylation in the heart.

Original languageEnglish (US)
Pages (from-to)140-158
Number of pages19
JournalAmerican Journal of Cardiovascular Disease
Volume4
Issue number4
StatePublished - Jan 1 2014

Keywords

  • Cardiac disease
  • Deneddylation
  • NEDD8
  • Neddylation
  • Post-translational modification

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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