Neonatal Microbiome and Its Relationship to Necrotizing Enterocolitis: A Review of the Science

Jordan Mattern, Terri Marin

Research output: Contribution to journalArticlepeer-review

Abstract

Necrotizing enterocolitis (NEC) occurs in many premature infants hospitalized in the neonatal intensive care unit. About 3% to 15% of very low-weight premature infants develop NEC, with an estimated 30% mortality rate for the cases requiring surgery. Currently, there is no known pathogenesis for NEC in the patient's populations. However, one of the most widely accepted hypotheses is having an abnormal fetal gut microbiome. The purpose of this review is to discuss some current methods of dysbiosis in the neonatal microbiome, such as maternal health, breastfeeding, and delivery method, and then to connect these to the occurrence of NEC in the infant and finally discuss some possibilities for limiting the occurrence of NEC in the future.

Original languageEnglish (US)
Pages (from-to)276-282
Number of pages7
JournalJournal of Perinatal and Neonatal Nursing
Volume34
Issue number3
DOIs
StatePublished - Jul 1 2020

Keywords

  • diseases of prematurity
  • dysbiosis
  • necrotizing enterocolitis
  • neonatal microbiome

ASJC Scopus subject areas

  • Pediatrics
  • Critical Care
  • Maternity and Midwifery

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