TY - JOUR
T1 - Neovascularization in atherectomy specimens from patients with unstable angina
T2 - Implications for pathogenesis of unstable angina
AU - Tenaglia, A. N.
AU - Peters, K. G.
AU - Sketch, Jr
AU - Annex, B. H.
PY - 1998
Y1 - 1998
N2 - Although neovascularization has been noted in atherosclerotic plaque, the presence of neovascularization has not been correlated with clinical syndromes. This study examined the relation between neovascularization in atherosclerotic plaque removed during directional coronary atherectomy and clinical status in 28 patients. Neovascularization was determined by immunohistochemistry with endothelial cell-specific monoclonal antibodies and was found in nine (50%) of 18 specimens from patients with unstable angina and in only one (10%) of 10 specimens from patients with stable angina (p < 0.05). There was no significant relation between neovascularization and other clinical factors (age, sex, race, hypertension, diabetes, tobacco use, hypercholesterolemia, positive family history of coronary artery disease, history of myocardial infarction, or stenosis severity). These results suggest that neovascularization may play a role in the pathogenesis of unstable angina.
AB - Although neovascularization has been noted in atherosclerotic plaque, the presence of neovascularization has not been correlated with clinical syndromes. This study examined the relation between neovascularization in atherosclerotic plaque removed during directional coronary atherectomy and clinical status in 28 patients. Neovascularization was determined by immunohistochemistry with endothelial cell-specific monoclonal antibodies and was found in nine (50%) of 18 specimens from patients with unstable angina and in only one (10%) of 10 specimens from patients with stable angina (p < 0.05). There was no significant relation between neovascularization and other clinical factors (age, sex, race, hypertension, diabetes, tobacco use, hypercholesterolemia, positive family history of coronary artery disease, history of myocardial infarction, or stenosis severity). These results suggest that neovascularization may play a role in the pathogenesis of unstable angina.
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U2 - 10.1016/S0002-8703(98)70336-9
DO - 10.1016/S0002-8703(98)70336-9
M3 - Article
C2 - 9453515
AN - SCOPUS:0031882931
SN - 0002-8703
VL - 135
SP - 10
EP - 14
JO - American Heart Journal
JF - American Heart Journal
IS - 1
ER -