Neural correlates of instrumental learning in primary auditory cortex

David Trumbull Blake, Fabrizio Strata, Anne K. Churchland, Michael M. Merzenich

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

In instrumental learning, Thorndike's law of effect states that stimulus-response relations are strengthened if they occur prior to positive reinforcement and weakened if they occur prior to negative reinforcement. In this study, we demonstrate that neural correlates of Thorndike's law may be observed in the primary auditory cortex, A1. Adult owl monkeys learned to discriminate tones higher than a standard frequency. Responses recorded from implanted microelectrodes initially exhibited broad spectral selectivity over a four-to-five octave range. With training, frequency discrimination thresholds changed from close to one octave to about 1/12 octave. Physiological recordings during the week in which the monkey came under behavioral control signaled by a drop in measured threshold had stronger responses to all frequencies. During the same week, A1 neural responses to target stimuli increased relative to standard and nontarget stimuli. This emergent difference in responsiveness persisted throughout the subsequent weeks of behavioral training. These data suggest that behavioral responses to stimuli modulate responsiveness in primary cortical areas.

Original languageEnglish (US)
Pages (from-to)10114-10119
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number15
DOIs
StatePublished - Jul 23 2002

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Operant Conditioning
Auditory Cortex
Aotidae
Microelectrodes
Haplorhini
Reinforcement (Psychology)
Discrimination (Psychology)

ASJC Scopus subject areas

  • General

Cite this

Neural correlates of instrumental learning in primary auditory cortex. / Blake, David Trumbull; Strata, Fabrizio; Churchland, Anne K.; Merzenich, Michael M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 15, 23.07.2002, p. 10114-10119.

Research output: Contribution to journalArticle

Blake, David Trumbull ; Strata, Fabrizio ; Churchland, Anne K. ; Merzenich, Michael M. / Neural correlates of instrumental learning in primary auditory cortex. In: Proceedings of the National Academy of Sciences of the United States of America. 2002 ; Vol. 99, No. 15. pp. 10114-10119.
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