Neural crest cells contribute to normal aorticopulmonary septation

Margaret L. Kirby, Thomas F Gale, Donald E. Stewart

Research output: Contribution to journalArticle

818 Citations (Scopus)

Abstract

By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.

Original languageEnglish (US)
Pages (from-to)1059-1061
Number of pages3
JournalScience
Volume220
Issue number4601
DOIs
StatePublished - Jan 1 1983

Fingerprint

Neural Crest
Somites
Transposition of Great Vessels
Quail
Population

ASJC Scopus subject areas

  • General

Cite this

Neural crest cells contribute to normal aorticopulmonary septation. / Kirby, Margaret L.; Gale, Thomas F; Stewart, Donald E.

In: Science, Vol. 220, No. 4601, 01.01.1983, p. 1059-1061.

Research output: Contribution to journalArticle

Kirby, Margaret L. ; Gale, Thomas F ; Stewart, Donald E. / Neural crest cells contribute to normal aorticopulmonary septation. In: Science. 1983 ; Vol. 220, No. 4601. pp. 1059-1061.
@article{a00ac1242a4c4669b32a634e1365998a,
title = "Neural crest cells contribute to normal aorticopulmonary septation",
abstract = "By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.",
author = "Kirby, {Margaret L.} and Gale, {Thomas F} and Stewart, {Donald E.}",
year = "1983",
month = "1",
day = "1",
doi = "10.1126/science.6844926",
language = "English (US)",
volume = "220",
pages = "1059--1061",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4601",

}

TY - JOUR

T1 - Neural crest cells contribute to normal aorticopulmonary septation

AU - Kirby, Margaret L.

AU - Gale, Thomas F

AU - Stewart, Donald E.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.

AB - By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.

UR - http://www.scopus.com/inward/record.url?scp=0020640517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020640517&partnerID=8YFLogxK

U2 - 10.1126/science.6844926

DO - 10.1126/science.6844926

M3 - Article

VL - 220

SP - 1059

EP - 1061

JO - Science

JF - Science

SN - 0036-8075

IS - 4601

ER -