Neural Substrates of Emotion As Revealed by Functional Magnetic Resonance Imaging

Gregory P. Lee, Kimford J. Meador, David W. Loring, Jerry D. Allison, Warren S. Brown, Lynn K. Paul, Jay J. Pillai, Thomas B. Lavin

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Objectives: To examine the brain circuitry involved in emotional experience and determine whether the cerebral hemispheres are specialized for positive and negative emotional experience. Background: Recent research has provided a preliminary sketch of the neurologic underpinnings of emotional processing involving specialized contributions of limbic and cortical brain regions. Electrophysiologic, functional imaging, and Wada test data have suggested positive, approach-related emotions are associated with left cerebral hemisphere regions, whereas negative, withdrawal-related emotions appear to be more aligned with right hemisphere mechanisms. Method: These emotional-neural associations were investigated using functional magnetic resonance imaging in 10 healthy controls with 20 positively and 20 negatively valenced pictures from the International Affective Picture System in a counterbalanced order. Pictures were viewed within a 1.5 Telsa scanner through computerized video goggles. Results: Emotional pictures resulted in significantly increased blood flow bilaterally in the mesial frontal lobe/anterior cingulate gyrus, dorsolateral frontal lobe, amygdala/anterior temporal regions, and cerebellum. Negative emotional pictures resulted in greater activation of the right hemisphere, and positive pictures caused greater activation of the left hemisphere. Conclusions: Results are consistent with theories emphasizing the importance of circuitry linking subcortical structures with mesial temporal, anterior cingulate, and frontal lobe regions in emotion and with the valence model of emotion that posits lateralized cerebral specialization for positive and negative emotional experience.

Original languageEnglish (US)
Pages (from-to)9-17
Number of pages9
JournalCognitive and Behavioral Neurology
Volume17
Issue number1
DOIs
StatePublished - Mar 1 2004

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Emotions
Frontal Lobe
Magnetic Resonance Imaging
Gyrus Cinguli
Cerebrum
Eye Protective Devices
Brain
Temporal Lobe
Amygdala
Cerebellum
Nervous System
Research

Keywords

  • Cerebral specialization
  • Emotion
  • Functional magnetic resonance imaging
  • Hemispheric specialization

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

Cite this

Neural Substrates of Emotion As Revealed by Functional Magnetic Resonance Imaging. / Lee, Gregory P.; Meador, Kimford J.; Loring, David W.; Allison, Jerry D.; Brown, Warren S.; Paul, Lynn K.; Pillai, Jay J.; Lavin, Thomas B.

In: Cognitive and Behavioral Neurology, Vol. 17, No. 1, 01.03.2004, p. 9-17.

Research output: Contribution to journalArticle

Lee, Gregory P. ; Meador, Kimford J. ; Loring, David W. ; Allison, Jerry D. ; Brown, Warren S. ; Paul, Lynn K. ; Pillai, Jay J. ; Lavin, Thomas B. / Neural Substrates of Emotion As Revealed by Functional Magnetic Resonance Imaging. In: Cognitive and Behavioral Neurology. 2004 ; Vol. 17, No. 1. pp. 9-17.
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