Neuregulin-1 Enhances Depolarization-Induced GABA Release

Ran Sook Woo, Xiao Ming Li, Yanmei Tao, Ezekiel Carpenter-Hyland, Yang Z. Huang, Janet Weber, Hannah Neiswender, Xian Ping Dong, Jiong Wu, Martin Gassmann, Cary Lai, Wencheng Xiong, Tian Ming Gao, Lin Mei

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Neuregulin-1 (NRG1), a regulator of neural development, has been shown to regulate neurotransmission at excitatory synapses. Although ErbB4, a key NRG1 receptor, is expressed in glutamic acid decarboxylase (GAD)-positive neurons, little is known about its role in GABAergic transmission. We show that ErbB4 is localized at GABAergic terminals of the prefrontal cortex. Our data indicate a role of NRG1, both endogenous and exogenous, in regulation of GABAergic transmission. This effect was blocked by inhibition or mutation of ErbB4, suggesting the involvement of ErbB4. Together, these results indicate that NRG1 regulates GABAergic transmission via presynaptic ErbB4 receptors, identifying a novel function of NRG1. Because both NRG1 and ErbB4 have emerged as susceptibility genes of schizophrenia, these observations may suggest a mechanism for abnormal GABAergic neurotransmission in this disorder.

Original languageEnglish (US)
Pages (from-to)599-610
Number of pages12
JournalNeuron
Volume54
Issue number4
DOIs
StatePublished - May 24 2007

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Neuregulin-1
gamma-Aminobutyric Acid
Synaptic Transmission
Presynaptic Receptors
Glutamate Decarboxylase
Prefrontal Cortex
Synapses
Schizophrenia
Neurons
Mutation
Genes

Keywords

  • HUMDISEASE
  • MOLNEURO
  • SYSNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Woo, R. S., Li, X. M., Tao, Y., Carpenter-Hyland, E., Huang, Y. Z., Weber, J., ... Mei, L. (2007). Neuregulin-1 Enhances Depolarization-Induced GABA Release. Neuron, 54(4), 599-610. https://doi.org/10.1016/j.neuron.2007.04.009

Neuregulin-1 Enhances Depolarization-Induced GABA Release. / Woo, Ran Sook; Li, Xiao Ming; Tao, Yanmei; Carpenter-Hyland, Ezekiel; Huang, Yang Z.; Weber, Janet; Neiswender, Hannah; Dong, Xian Ping; Wu, Jiong; Gassmann, Martin; Lai, Cary; Xiong, Wencheng; Gao, Tian Ming; Mei, Lin.

In: Neuron, Vol. 54, No. 4, 24.05.2007, p. 599-610.

Research output: Contribution to journalArticle

Woo, RS, Li, XM, Tao, Y, Carpenter-Hyland, E, Huang, YZ, Weber, J, Neiswender, H, Dong, XP, Wu, J, Gassmann, M, Lai, C, Xiong, W, Gao, TM & Mei, L 2007, 'Neuregulin-1 Enhances Depolarization-Induced GABA Release', Neuron, vol. 54, no. 4, pp. 599-610. https://doi.org/10.1016/j.neuron.2007.04.009
Woo RS, Li XM, Tao Y, Carpenter-Hyland E, Huang YZ, Weber J et al. Neuregulin-1 Enhances Depolarization-Induced GABA Release. Neuron. 2007 May 24;54(4):599-610. https://doi.org/10.1016/j.neuron.2007.04.009
Woo, Ran Sook ; Li, Xiao Ming ; Tao, Yanmei ; Carpenter-Hyland, Ezekiel ; Huang, Yang Z. ; Weber, Janet ; Neiswender, Hannah ; Dong, Xian Ping ; Wu, Jiong ; Gassmann, Martin ; Lai, Cary ; Xiong, Wencheng ; Gao, Tian Ming ; Mei, Lin. / Neuregulin-1 Enhances Depolarization-Induced GABA Release. In: Neuron. 2007 ; Vol. 54, No. 4. pp. 599-610.
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