Neuregulin-1 temperature-dependently inhibits the long-term potentiation in the CA1 region in mouse hippocampal slices

Yongjun Chen, Meng Zhang, P. Wang, Xin hong Zhu, Tian ming Gao

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Abstract

OBJECTIVE: To investigate the effect of neurogulin-1 (NRG1) on the transmission and plasticity of CA1 synapses in mouse hippocampal slices at different temperatures. METHODS: Under room temperature (26-/+1 degrees C) or physiological temperature (32-/+1 degrees C), field excitatory postsynaptic potential (fEPSP) evoked by extracellular microelectrode recording technique was recorded in the CA1 region in adult mouse hippocampal slices, and the long-term potentiation (LTP) was induced by high frequency stimulation (HFS). The effects of NRG1 on the baseline fEPSP and induction of LTP in CA1 region were observed. RESULTS: No significant variation in the slope of fEPSP relative to the baseline fEPSP was observed after perfusion with NRG1 at room temperature or physiological temperature (P > 0.05). After HFS at the room temperature, the mean slope of fEPSP in the slices perfused with NRG1 was similar to that of the control group (P > 0.05), but HFS at the physiological temperature resulted in significant reduction in the mean slope of fEPSP in the slices perfused with NRG1 (P < 0.01). CONCLUSION: NRG1 may temperature-dependently inhibit the induction of LTP in the CA1 region in mouse hippocampal slices.

Original languageEnglish (US)
Pages (from-to)1771-1774
Number of pages4
JournalNan fang yi ke da xue xue bao = Journal of Southern Medical University
Volume28
Issue number10
StatePublished - Jan 1 2008

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Neuregulin-1
Long-Term Potentiation
Excitatory Postsynaptic Potentials
Temperature
Microelectrodes
Synapses
Perfusion
Control Groups

ASJC Scopus subject areas

  • Medicine(all)

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Neuregulin-1 temperature-dependently inhibits the long-term potentiation in the CA1 region in mouse hippocampal slices. / Chen, Yongjun; Zhang, Meng; Wang, P.; Zhu, Xin hong; Gao, Tian ming.

In: Nan fang yi ke da xue xue bao = Journal of Southern Medical University, Vol. 28, No. 10, 01.01.2008, p. 1771-1774.

Research output: Contribution to journalArticle

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AU - Gao, Tian ming

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AB - OBJECTIVE: To investigate the effect of neurogulin-1 (NRG1) on the transmission and plasticity of CA1 synapses in mouse hippocampal slices at different temperatures. METHODS: Under room temperature (26-/+1 degrees C) or physiological temperature (32-/+1 degrees C), field excitatory postsynaptic potential (fEPSP) evoked by extracellular microelectrode recording technique was recorded in the CA1 region in adult mouse hippocampal slices, and the long-term potentiation (LTP) was induced by high frequency stimulation (HFS). The effects of NRG1 on the baseline fEPSP and induction of LTP in CA1 region were observed. RESULTS: No significant variation in the slope of fEPSP relative to the baseline fEPSP was observed after perfusion with NRG1 at room temperature or physiological temperature (P > 0.05). After HFS at the room temperature, the mean slope of fEPSP in the slices perfused with NRG1 was similar to that of the control group (P > 0.05), but HFS at the physiological temperature resulted in significant reduction in the mean slope of fEPSP in the slices perfused with NRG1 (P < 0.01). CONCLUSION: NRG1 may temperature-dependently inhibit the induction of LTP in the CA1 region in mouse hippocampal slices.

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