Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases

Lin Mei, Klaus Armin Nave

Research output: Contribution to journalReview article

202 Citations (Scopus)

Abstract

Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility genes for diseases such as schizophrenia (SZ) and bipolar disorder. Recent studies have revealed complex Nrg/Erbb signaling networks that regulate the assembly of neural circuitry, myelination, neurotransmission, and synaptic plasticity. Evidence indicates there is an optimal level of NRG/ERBB signaling in the brain and deviation from it impairs brain functions. NRGs/ERBBs and downstream signaling pathways may provide therapeutic targets for specific neuropsychiatric symptoms. Neuregulins (NRGs) comprise a family of growth factors that activate ERBB receptor kinases. Mei and Nave review the role of Nrg-Erbb signaling in neural development, myelination, and synaptic plasticity and the possible contribution of abnormal NRG1 signaling to brain disorders.

Original languageEnglish (US)
Pages (from-to)27-49
Number of pages23
JournalNeuron
Volume83
Issue number1
DOIs
StatePublished - Jul 2 2014

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Neuregulins
Nervous System Diseases
Neuronal Plasticity
Intercellular Signaling Peptides and Proteins
Disease Susceptibility
Brain
Receptor Protein-Tyrosine Kinases
Brain Diseases
Bipolar Disorder
Synaptic Transmission
Schizophrenia
Phosphotransferases
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. / Mei, Lin; Nave, Klaus Armin.

In: Neuron, Vol. 83, No. 1, 02.07.2014, p. 27-49.

Research output: Contribution to journalReview article

Mei, Lin ; Nave, Klaus Armin. / Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. In: Neuron. 2014 ; Vol. 83, No. 1. pp. 27-49.
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