Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility genes for diseases such as schizophrenia (SZ) and bipolar disorder. Recent studies have revealed complex Nrg/Erbb signaling networks that regulate the assembly of neural circuitry, myelination, neurotransmission, and synaptic plasticity. Evidence indicates there is an optimal level of NRG/ERBB signaling in the brain and deviation from it impairs brain functions. NRGs/ERBBs and downstream signaling pathways may provide therapeutic targets for specific neuropsychiatric symptoms. Neuregulins (NRGs) comprise a family of growth factors that activate ERBB receptor kinases. Mei and Nave review the role of Nrg-Erbb signaling in neural development, myelination, and synaptic plasticity and the possible contribution of abnormal NRG1 signaling to brain disorders.
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