Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors

Xiao Li Yang, Yang Z. Huang, Wen C. Xiong, Lin Mei

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Neuregulin-induced expression of the acetylcholine receptor (AChR) contributes to high concentration of the receptor at the neuromuscular junction (NMJ). Neuregulin-1 activates ErbB tyrosine kinases and subsequently intracellular kinases including Erk that is required for induced AChR expression. Recent studies demonstrate that ligand-induced internalization may regulate signaling of various receptor tyrosine kinases. However, the role of induced ErbB endocytosis in regulating AChR expression was unclear. Here we provide evidence that ErbB tyrosine kinases became rapidly internalized in response to neuregulin. The internalization required the kinase activity of ErbB proteins and involved a clathrin-dependent endocytic pathway. Moreover, neuregulin-induced Erk activation and AChR expression were attenuated when ErbB endocytosis was blocked. These results indicate that ErbB proteins undergo endocytosis in response to neuregulin, and this process is required for neuregulin signaling and induced AChR expression.

Original languageEnglish (US)
Pages (from-to)335-346
Number of pages12
JournalMolecular and Cellular Neuroscience
Volume28
Issue number2
DOIs
StatePublished - Feb 2005

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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