NeuroD/Beta2 polymorphism is not associated with type 1 diabetes in Chinese, Korean, or Caucasian populations

Michele P. Marron, Diane I. Hopkins, Jin Xiong She, Yong Soo Park, Jin Xiong She

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A recent case-control study in the Japanese population has shown association of type 1 diabetes with a guanine (G) to adenine (A) change in the nucleotide sequence (Ala45→Thr) of the transcription factor NeuroD/Beta2 on chromosome 2q32. However, this polymorphic marker showed no evidence of association in case-control or familial studies in a Caucasian population. In an effort to confirm the association of NeuroD/Beta2 polymorphisms with type 1 diabetes, we analyzed the A/G polymorphism in Chinese, Korean and Caucasian populations. Our studies in a much larger data set revealed no evidence of association in these populations.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalJournal of Endocrine Genetics
Volume1
Issue number2
StatePublished - Apr 1999

Keywords

  • Association
  • Beta2
  • Linkage
  • NeuroD
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Genetics
  • Genetics(clinical)

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