NeuroD/Beta2 polymorphism is not associated with type 1 diabetes in Chinese, Korean, or Caucasian populations

Michele P. Marron; Diane I. Hopkins; Jin Xiong She; Yong Soo Park; Jin Xiong She

NeuroD/Beta2 polymorphism is not associated with type 1 diabetes in Chinese, Korean, or Caucasian populations

Michele P. Marron, Diane I. Hopkins, Jin Xiong She, Yong Soo Park, Jin Xiong She

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A recent case-control study in the Japanese population has shown association of type 1 diabetes with a guanine (G) to adenine (A) change in the nucleotide sequence (Ala45→Thr) of the transcription factor NeuroD/Beta2 on chromosome 2q32. However, this polymorphic marker showed no evidence of association in case-control or familial studies in a Caucasian population. In an effort to confirm the association of NeuroD/Beta2 polymorphisms with type 1 diabetes, we analyzed the A/G polymorphism in Chinese, Korean and Caucasian populations. Our studies in a much larger data set revealed no evidence of association in these populations.

Original language	English (US)
Pages (from-to)	73-77
Number of pages	5
Journal	Journal of Endocrine Genetics
Volume	1
Issue number	2
State	Published - Apr 1999

Keywords

Association
Beta2
Linkage
NeuroD
Type 1 diabetes

ASJC Scopus subject areas

Endocrinology
Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "NeuroD/Beta2 polymorphism is not associated with type 1 diabetes in Chinese, Korean, or Caucasian populations",

abstract = "A recent case-control study in the Japanese population has shown association of type 1 diabetes with a guanine (G) to adenine (A) change in the nucleotide sequence (Ala45→Thr) of the transcription factor NeuroD/Beta2 on chromosome 2q32. However, this polymorphic marker showed no evidence of association in case-control or familial studies in a Caucasian population. In an effort to confirm the association of NeuroD/Beta2 polymorphisms with type 1 diabetes, we analyzed the A/G polymorphism in Chinese, Korean and Caucasian populations. Our studies in a much larger data set revealed no evidence of association in these populations.",

keywords = "Association, Beta2, Linkage, NeuroD, Type 1 diabetes",

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journal = "Journal of Endocrine Genetics",

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T1 - NeuroD/Beta2 polymorphism is not associated with type 1 diabetes in Chinese, Korean, or Caucasian populations

AU - Marron, Michele P.

AU - Hopkins, Diane I.

AU - She, Jin Xiong

AU - Park, Yong Soo

AU - She, Jin Xiong

PY - 1999/4

Y1 - 1999/4

N2 - A recent case-control study in the Japanese population has shown association of type 1 diabetes with a guanine (G) to adenine (A) change in the nucleotide sequence (Ala45→Thr) of the transcription factor NeuroD/Beta2 on chromosome 2q32. However, this polymorphic marker showed no evidence of association in case-control or familial studies in a Caucasian population. In an effort to confirm the association of NeuroD/Beta2 polymorphisms with type 1 diabetes, we analyzed the A/G polymorphism in Chinese, Korean and Caucasian populations. Our studies in a much larger data set revealed no evidence of association in these populations.

AB - A recent case-control study in the Japanese population has shown association of type 1 diabetes with a guanine (G) to adenine (A) change in the nucleotide sequence (Ala45→Thr) of the transcription factor NeuroD/Beta2 on chromosome 2q32. However, this polymorphic marker showed no evidence of association in case-control or familial studies in a Caucasian population. In an effort to confirm the association of NeuroD/Beta2 polymorphisms with type 1 diabetes, we analyzed the A/G polymorphism in Chinese, Korean and Caucasian populations. Our studies in a much larger data set revealed no evidence of association in these populations.

KW - Association

KW - Beta2

KW - Linkage

KW - NeuroD

KW - Type 1 diabetes

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ER -

NeuroD/Beta2 polymorphism is not associated with type 1 diabetes in Chinese, Korean, or Caucasian populations

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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