Abstract
A recent case-control study in the Japanese population has shown association of type 1 diabetes with a guanine (G) to adenine (A) change in the nucleotide sequence (Ala45→Thr) of the transcription factor NeuroD/Beta2 on chromosome 2q32. However, this polymorphic marker showed no evidence of association in case-control or familial studies in a Caucasian population. In an effort to confirm the association of NeuroD/Beta2 polymorphisms with type 1 diabetes, we analyzed the A/G polymorphism in Chinese, Korean and Caucasian populations. Our studies in a much larger data set revealed no evidence of association in these populations.
Original language | English (US) |
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Pages (from-to) | 73-77 |
Number of pages | 5 |
Journal | Journal of Endocrine Genetics |
Volume | 1 |
Issue number | 2 |
State | Published - Apr 1999 |
Keywords
- Association
- Beta2
- Linkage
- NeuroD
- Type 1 diabetes
ASJC Scopus subject areas
- Endocrinology
- Genetics
- Genetics(clinical)