Neuroendocrine Regulation of Anxiety: Beyond the Hypothalamic-Pituitary-Adrenal Axis

A. P. Borrow, A. M. Stranahan, D. Suchecki, R. Yunes

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

The central nervous system regulates and responds to endocrine signals, and this reciprocal relationship determines emotional processing and behavioural anxiety. Although the hypothalamic-pituitary-adrenal (HPA) axis remains the best-characterised system for this relationship, other steroid and peptide hormones are increasingly recognised for their effects on anxiety-like behaviour and reward. The present review examines recent developments related to the role of a number of different hormones in anxiety, including pregnane neurosteroids, gut peptides, neuropeptides and hormonal signals derived from fatty acids. Findings from both basic and clinical studies suggest that these alternative systems may complement or occlude stress-induced changes in anxiety and anxiety-like behaviour. By broadening the scope of mechanisms for depression and anxiety, it may be possible to develop novel strategies to attenuate stress-related psychiatric conditions. The targets for these potential therapies, as discussed in this review, encompass multiple circuits and systems, including those outside of the HPA axis.

Original languageEnglish (US)
JournalJournal of Neuroendocrinology
Volume28
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

Anxiety
Pregnanes
Peptide Hormones
Neuropeptides
Reward
Neurotransmitter Agents
Psychiatry
Fatty Acids
Central Nervous System
Steroids
Hormones
Depression
Peptides
Therapeutics

Keywords

  • anxiety
  • behaviour
  • neuropeptides
  • neurosteroids

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Cite this

Neuroendocrine Regulation of Anxiety : Beyond the Hypothalamic-Pituitary-Adrenal Axis. / Borrow, A. P.; Stranahan, A. M.; Suchecki, D.; Yunes, R.

In: Journal of Neuroendocrinology, Vol. 28, No. 7, 01.07.2016.

Research output: Contribution to journalReview article

@article{1fe4205b578d4d2dbe6baf55a0c4b055,
title = "Neuroendocrine Regulation of Anxiety: Beyond the Hypothalamic-Pituitary-Adrenal Axis",
abstract = "The central nervous system regulates and responds to endocrine signals, and this reciprocal relationship determines emotional processing and behavioural anxiety. Although the hypothalamic-pituitary-adrenal (HPA) axis remains the best-characterised system for this relationship, other steroid and peptide hormones are increasingly recognised for their effects on anxiety-like behaviour and reward. The present review examines recent developments related to the role of a number of different hormones in anxiety, including pregnane neurosteroids, gut peptides, neuropeptides and hormonal signals derived from fatty acids. Findings from both basic and clinical studies suggest that these alternative systems may complement or occlude stress-induced changes in anxiety and anxiety-like behaviour. By broadening the scope of mechanisms for depression and anxiety, it may be possible to develop novel strategies to attenuate stress-related psychiatric conditions. The targets for these potential therapies, as discussed in this review, encompass multiple circuits and systems, including those outside of the HPA axis.",
keywords = "anxiety, behaviour, neuropeptides, neurosteroids",
author = "Borrow, {A. P.} and Stranahan, {A. M.} and D. Suchecki and R. Yunes",
year = "2016",
month = "7",
day = "1",
doi = "10.1111/jne.12403",
language = "English (US)",
volume = "28",
journal = "Journal of Neuroendocrinology",
issn = "0953-8194",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Neuroendocrine Regulation of Anxiety

T2 - Beyond the Hypothalamic-Pituitary-Adrenal Axis

AU - Borrow, A. P.

AU - Stranahan, A. M.

AU - Suchecki, D.

AU - Yunes, R.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - The central nervous system regulates and responds to endocrine signals, and this reciprocal relationship determines emotional processing and behavioural anxiety. Although the hypothalamic-pituitary-adrenal (HPA) axis remains the best-characterised system for this relationship, other steroid and peptide hormones are increasingly recognised for their effects on anxiety-like behaviour and reward. The present review examines recent developments related to the role of a number of different hormones in anxiety, including pregnane neurosteroids, gut peptides, neuropeptides and hormonal signals derived from fatty acids. Findings from both basic and clinical studies suggest that these alternative systems may complement or occlude stress-induced changes in anxiety and anxiety-like behaviour. By broadening the scope of mechanisms for depression and anxiety, it may be possible to develop novel strategies to attenuate stress-related psychiatric conditions. The targets for these potential therapies, as discussed in this review, encompass multiple circuits and systems, including those outside of the HPA axis.

AB - The central nervous system regulates and responds to endocrine signals, and this reciprocal relationship determines emotional processing and behavioural anxiety. Although the hypothalamic-pituitary-adrenal (HPA) axis remains the best-characterised system for this relationship, other steroid and peptide hormones are increasingly recognised for their effects on anxiety-like behaviour and reward. The present review examines recent developments related to the role of a number of different hormones in anxiety, including pregnane neurosteroids, gut peptides, neuropeptides and hormonal signals derived from fatty acids. Findings from both basic and clinical studies suggest that these alternative systems may complement or occlude stress-induced changes in anxiety and anxiety-like behaviour. By broadening the scope of mechanisms for depression and anxiety, it may be possible to develop novel strategies to attenuate stress-related psychiatric conditions. The targets for these potential therapies, as discussed in this review, encompass multiple circuits and systems, including those outside of the HPA axis.

KW - anxiety

KW - behaviour

KW - neuropeptides

KW - neurosteroids

UR - http://www.scopus.com/inward/record.url?scp=84978906731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978906731&partnerID=8YFLogxK

U2 - 10.1111/jne.12403

DO - 10.1111/jne.12403

M3 - Review article

C2 - 27318180

AN - SCOPUS:84978906731

VL - 28

JO - Journal of Neuroendocrinology

JF - Journal of Neuroendocrinology

SN - 0953-8194

IS - 7

ER -