Neuroimaging and transcranial ultrasonography in Parkinson's disease

Shyamal H. Mehta, John Christopher Morgan, Kapil Dev Sethi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Parkinson's disease is a progressive, widespread, neurodegenerative disease in which the involvement of the dopaminergic neurons of the substantia nigra results in significant dopamine depletion in the striatum. Newer imaging modalities reviewed here, using various radioligands, positron emission tomography, and single-photon emission computed tomography, have made it possible to assess the in vivo presynaptic and postsynaptic dopaminergic function. This is not only important from a diagnostic standpoint; these tests are being increasingly studied as surrogate markers to assess disease progression and responses to various interventions, including drugs. A brief comment on their role as a putative biomarker of the disease is also included. Because Parkinson's disease involves multiple neurotransmitter systems, neuroimaging of neurotransmitter systems other than dopamine is also discussed. Lastly, the evidence supporting the use of transcranial ultrasonography and substantia nigra hyperechogenicity in the diagnosis of Parkinson's disease is presented, along with some controversies that surround this technique.

Original languageEnglish (US)
Pages (from-to)297-303
Number of pages7
JournalCurrent Neurology and Neuroscience Reports
Volume8
Issue number4
DOIs
StatePublished - Dec 1 2008

Fingerprint

Neuroimaging
Parkinson Disease
Ultrasonography
Substantia Nigra
Neurotransmitter Agents
Dopamine
Biomarkers
Dopaminergic Neurons
Single-Photon Emission-Computed Tomography
Neurodegenerative Diseases
Positron-Emission Tomography
Disease Progression
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Neuroimaging and transcranial ultrasonography in Parkinson's disease. / Mehta, Shyamal H.; Morgan, John Christopher; Sethi, Kapil Dev.

In: Current Neurology and Neuroscience Reports, Vol. 8, No. 4, 01.12.2008, p. 297-303.

Research output: Contribution to journalArticle

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