Neuroimaging Issues in Assessing Response to Brain Tumor Therapy

Brendan J. McCullough; John W. Henson

doi:10.1016/B978-0-12-800945-1.00054-9

Neuroimaging Issues in Assessing Response to Brain Tumor Therapy

Brendan J. McCullough, John W. Henson

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Magnetic resonance imaging is an indispensable tool for both day-to-day management of brain tumor patients and neuro-oncology clinical trails. While recognizing the value of neuroimaging, there are a number of technical difficulties in the serial measurement of brain tumors, as well as uncertainties about the meaning of the information obtained. In this chapter, we first discuss the imaging appearance and behavior of common adult primary brain tumors. We then review various methods in practice used for the measurement and classification of response to treatment or progression of disease. Finally, we explore the challenges of using imaging as a surrogate measure of pathology.

Original language	English (US)
Title of host publication	Handbook of Neuro-Oncology Neuroimaging
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	667-680
Number of pages	14
ISBN (Electronic)	9780128011683
ISBN (Print)	9780128009451
DOIs	https://doi.org/10.1016/B978-0-12-800945-1.00054-9
State	Published - Apr 12 2016
Externally published	Yes

Keywords

Progression
Pseudoprogression
Pseudoresponse
RANO (Response Assessment Neuro-oncology)
Research
Response
Trial

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-800945-1.00054-9

Cite this

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abstract = "Magnetic resonance imaging is an indispensable tool for both day-to-day management of brain tumor patients and neuro-oncology clinical trails. While recognizing the value of neuroimaging, there are a number of technical difficulties in the serial measurement of brain tumors, as well as uncertainties about the meaning of the information obtained. In this chapter, we first discuss the imaging appearance and behavior of common adult primary brain tumors. We then review various methods in practice used for the measurement and classification of response to treatment or progression of disease. Finally, we explore the challenges of using imaging as a surrogate measure of pathology.",

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AB - Magnetic resonance imaging is an indispensable tool for both day-to-day management of brain tumor patients and neuro-oncology clinical trails. While recognizing the value of neuroimaging, there are a number of technical difficulties in the serial measurement of brain tumors, as well as uncertainties about the meaning of the information obtained. In this chapter, we first discuss the imaging appearance and behavior of common adult primary brain tumors. We then review various methods in practice used for the measurement and classification of response to treatment or progression of disease. Finally, we explore the challenges of using imaging as a surrogate measure of pathology.

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KW - Pseudoprogression

KW - Pseudoresponse

KW - RANO (Response Assessment Neuro-oncology)

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KW - Response

KW - Trial

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M3 - Chapter

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BT - Handbook of Neuro-Oncology Neuroimaging

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ER -

Neuroimaging Issues in Assessing Response to Brain Tumor Therapy

Abstract

Keywords

ASJC Scopus subject areas

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