Neuroimaging Issues in Assessing Response to Brain Tumor Therapy

Brendan J. McCullough, John W. Henson

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Magnetic resonance imaging is an indispensable tool for both day-to-day management of brain tumor patients and neuro-oncology clinical trails. While recognizing the value of neuroimaging, there are a number of technical difficulties in the serial measurement of brain tumors, as well as uncertainties about the meaning of the information obtained. In this chapter, we first discuss the imaging appearance and behavior of common adult primary brain tumors. We then review various methods in practice used for the measurement and classification of response to treatment or progression of disease. Finally, we explore the challenges of using imaging as a surrogate measure of pathology.

Original languageEnglish (US)
Title of host publicationHandbook of Neuro-Oncology Neuroimaging
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages14
ISBN (Electronic)9780128011683
ISBN (Print)9780128009451
StatePublished - Apr 12 2016
Externally publishedYes


  • Progression
  • Pseudoprogression
  • Pseudoresponse
  • RANO (Response Assessment Neuro-oncology)
  • Research
  • Response
  • Trial

ASJC Scopus subject areas

  • Medicine(all)


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