Neurologic toxicity associated with hepatic artery infusion HAI of FUdR

H. Grant Taylor, Charles R. Wolf, Charles G. Maitland

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 66-year-old man with hepatic metastases from gastric adenocarcinoma was treated on two occasions with 5-fluoro-2-deoxyuridine (FUdR) via hepatic artery infusion (HAI). The patient developed neurologic signs and symptoms including disorientation, oculomotor defects, ataxia and multifocal myoclonus during both attempts at HAI. Systemic drug toxicity is unusual when FUdR is given via HAI, and neurologic toxicity has not previously been reported. We postulate individual hypersensitivity to FUdR or selective concentration of FUdR in brainstem structures to explain the toxicity in this case.

Original languageEnglish (US)
Pages (from-to)292-293
Number of pages2
JournalCancer Chemotherapy and Pharmacology
Volume17
Issue number3
DOIs
StatePublished - Jul 1 1986

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Deoxyuridine
Hepatic Artery
Nervous System
Toxicity
Neurologic Manifestations
Drug-Related Side Effects and Adverse Reactions
Brain Stem
Stomach
Hypersensitivity
Adenocarcinoma
Neoplasm Metastasis
Defects
Liver
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

Cite this

Neurologic toxicity associated with hepatic artery infusion HAI of FUdR. / Grant Taylor, H.; Wolf, Charles R.; Maitland, Charles G.

In: Cancer Chemotherapy and Pharmacology, Vol. 17, No. 3, 01.07.1986, p. 292-293.

Research output: Contribution to journalArticle

Grant Taylor, H. ; Wolf, Charles R. ; Maitland, Charles G. / Neurologic toxicity associated with hepatic artery infusion HAI of FUdR. In: Cancer Chemotherapy and Pharmacology. 1986 ; Vol. 17, No. 3. pp. 292-293.
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