Neuroprotection offered by Majun Khadar, a traditional Unani medicine, during cerebral ischemic damage in rats

Fakhrul Islam, Seema Yousuf, Fahim Atif, Muzamil Ahmad, Tauheed Ishrat, Badruzzaman Khan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Stroke results in damages to many biochemical, molecular and behavioral deficits. Present study provides evidence of the protective efficacy of a Unani herbal medicine, Majun Khadar (MK), against cerebral ischemia-induced behavioral dysfunctions and neurochemical alterations in the hippocampus (HIP). Transient focal cerebral ischemia was induced for 2 h followed by reperfusion for 22 h in a rat model. Rats were divided into four groups: sham, middle cerebral artery occluded (MCAO), drug sham (MK; 0.816gkg-1 orally for 15 days) and MK pre-treated ischemic group (MK + MCAO). Levels of enzymatic and non-enzymatic antioxidants were estimated in HIP along with behavioral testing. MK pre-treatment significantly (P <.05-.001) restored the activities of glutathione peroxidase (GP×), glutathione reductase (GR), glutathione S-transferase (GST) and decreased the level of lipid peroxidation (LPO) and H2O2 content in HIP in the MK + MCAO group which were severely altered in the MCAO group. The content of glutathione (GSH), total thiols (TT) and ascorbic acid (AsA) was significantly depleted in the MCAO group; pretreatment with MK was able to restore its levels. Also in the MK + MCAO group, significant (P <.5-.001) recovery in behavioral testing by rota rod and open-field activities was seen as compared with the MCAO group. MK alone did not show any change neither in the status of various antioxidants nor behavioral functions over sham values. Although detailed studies are required for the evaluation of exact neuroprotective mechanism of MK against cerebral ischemia these preliminary experimental findings conclude that MK exhibits neuroprotective effect in cerebral ischemia by potentiating the antioxidant defense system of the brain.

Original languageEnglish (US)
Article number754025
JournalEvidence-based Complementary and Alternative Medicine
Volume2011
DOIs
StatePublished - Sep 16 2011

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Unani Medicine
Middle Cerebral Artery
Traditional Medicine
Brain Ischemia
Hippocampus
Antioxidants
Glutathione Reductase
Herbal Medicine
Transient Ischemic Attack
Neuroprotective Agents
Glutathione Peroxidase
Neuroprotection
Glutathione Transferase
Sulfhydryl Compounds
Lipid Peroxidation
Ascorbic Acid
Reperfusion
Glutathione
Stroke

ASJC Scopus subject areas

  • Complementary and alternative medicine

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Neuroprotection offered by Majun Khadar, a traditional Unani medicine, during cerebral ischemic damage in rats. / Islam, Fakhrul; Yousuf, Seema; Atif, Fahim; Ahmad, Muzamil; Ishrat, Tauheed; Khan, Badruzzaman.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2011, 754025, 16.09.2011.

Research output: Contribution to journalArticle

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