Neurosarcoidosis with necrotising sarcoid granulomatosis mimicking meningiomatosis cerebri: Case report and literature search

Natasha Marie Savage, Hemang Shah, Cargill Herley Alleyne, Jeffrey A Switzer, Jeffrey R Lee, John Steele, Suash Sharma

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 52-year-old woman presented with headaches, difficulty with word finding and left eye blindness. MRI showed enhancing frontal dural-based masses suggestive of meningiomatosis. Biopsy and debulking revealed necrotising granulomas, without discernible micro-organisms or neoplasia; a thorough clinical work-up was negative for infection and vasculitis. A CT scan showed mild bilateral hilar lymphadenopathy, a tiny pulmonary nodule and cirrhotic liver. Her subsequent alteration of mental status was attributed to hepatic encephalopathy based upon elevated aminotransferase and ammonia levels, biopsy evidence of hepatoportal sclerosis with rare granulomas and response to lactulose. A diagnosis of neurosarcoidosis of the necrotising sarcoid granulomatosis variant (NS-NSG) with atypical systemic involvement was made. This is the fifth case report of NS-NSG clinically mimicking a neoplasm and histologically mimicking a mycobacterial infection. NS-NSG can have an atypical clinical picture including intracranial masses; a thorough work-up to exclude infectious and other non-infectious aetiologies is a prerequisite to its diagnosis.

Original languageEnglish (US)
Article number1187
JournalBMJ Case Reports
DOIs
StatePublished - May 25 2009

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Meningioma
Granuloma
Lactulose
Biopsy
Hepatic Encephalopathy
Sclerosis
Blindness
Vasculitis
Transaminases
Infection
Ammonia
Headache
Neoplasms
Lung
Liver
Neurosarcoidosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neurosarcoidosis with necrotising sarcoid granulomatosis mimicking meningiomatosis cerebri : Case report and literature search. / Savage, Natasha Marie; Shah, Hemang; Alleyne, Cargill Herley; Switzer, Jeffrey A; Lee, Jeffrey R; Steele, John; Sharma, Suash.

In: BMJ Case Reports, 25.05.2009.

Research output: Contribution to journalArticle

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