Neurotensin is an autocrine trophic factor stimulated by androgen withdrawal in human prostate cancer

Inder Sehgal, Stephen Powers, Brenda Huntley, Garth Powis, Mark Pittelkow, Nita Jane Maihle

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

After therapeutic hormone deprivation, prostate cancer cells often develop androgen-insensitive growth through mechanisms thus far undefined. Neuropeptides have been previously implicated as growth factors in some prostate cancers. Here, we demonstrate that androgen-sensitive LNCaP human prostate cancer cells produce and secrete neurotensin following androgen withdrawal. We show that while LNCaP cells express the neurotensin receptor, only androgen-deprived cells exhibit a growth response to exogenous neurotensin. We further demonstrate that androgen-stimulated cells may be refractory to exogenous neurotensin due to androgen induction of a metalloprotease active toward neurotensin. Thus, prostate cancer cells deprived of androgen develop an alternative autocrine growth mechanism involving neurotensin.

Original languageEnglish (US)
Pages (from-to)4673-4677
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number11
DOIs
StatePublished - May 24 1994

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Neurotensin
Androgens
Prostatic Neoplasms
Growth
Neurotensin Receptors
Metalloproteases
Neuropeptides
Intercellular Signaling Peptides and Proteins
Hormones

Keywords

  • growth factor
  • neuroendocrine

ASJC Scopus subject areas

  • General

Cite this

Neurotensin is an autocrine trophic factor stimulated by androgen withdrawal in human prostate cancer. / Sehgal, Inder; Powers, Stephen; Huntley, Brenda; Powis, Garth; Pittelkow, Mark; Maihle, Nita Jane.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, No. 11, 24.05.1994, p. 4673-4677.

Research output: Contribution to journalArticle

Sehgal, Inder ; Powers, Stephen ; Huntley, Brenda ; Powis, Garth ; Pittelkow, Mark ; Maihle, Nita Jane. / Neurotensin is an autocrine trophic factor stimulated by androgen withdrawal in human prostate cancer. In: Proceedings of the National Academy of Sciences of the United States of America. 1994 ; Vol. 91, No. 11. pp. 4673-4677.
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