Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications

Research output: Contribution to journalReview article

369 Citations (Scopus)

Abstract

Estrogen is an important hormone signal that regulates multiple tissues and functions in the body. This review focuses on the neurotrophic and neuroprotective actions of estrogen in the brain, with particular emphasis on estrogen actions in the hippocampus, cerebral cortex and striatum. Sex differences in the risk, onset and severity of neurodegenerative disease such as Alzheimer's disease, Parkinson's disease and stroke are well known, and the potential role of estrogen as a neuroprotective factor is discussed in this context. The review assimilates a complex literature that spans research in humans, non-human primates and rodent animal models and attempts to contrast and compare the findings across species where possible. Current controversies regarding the Women's Health Initiative (WHI) study, its ramifications, concerns and the new studies needed to address these concerns are also addressed. Signaling mechanisms underlying estrogen-induced neuroprotection and synaptic plasticity are reviewed, including the important concepts of genomic versus nongenomic mechanisms, types of estrogen receptor involved and their subcellular targeting, and implicated downstream signaling pathways and mediators. Finally, a multicellular mode of estrogen action in the regulation of neuronal survival and neurotrophism is discussed, as are potential future directions for the field.

Original languageEnglish (US)
Pages (from-to)381-405
Number of pages25
JournalSteroids
Volume72
Issue number5
DOIs
StatePublished - May 1 2007

Fingerprint

Estrogens
Neurodegenerative diseases
Neuronal Plasticity
Women's Health
Sex Characteristics
Estrogen Receptors
Neurodegenerative Diseases
Cerebral Cortex
Primates
Plasticity
Parkinson Disease
Rodentia
Hippocampus
Brain
Alzheimer Disease
Animals
Animal Models
Stroke
Hormones
Tissue

Keywords

  • Alzheimer's disease
  • Estrogen
  • Neuroprotection
  • Parkinson disease
  • Stroke
  • Synaptic plasticity

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Neurotrophic and neuroprotective actions of estrogen : Basic mechanisms and clinical implications. / Brann, Darrell W; Dhandapani, Krishnan Michael; Wakade, Chandramohan G.; Mahesh, Virendra B.; Khan, Mohammad M.

In: Steroids, Vol. 72, No. 5, 01.05.2007, p. 381-405.

Research output: Contribution to journalReview article

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