Neurotrophins and schizophrenia

Peter F. Buckley, Sahebarao Mahadik, Anilkumar Pillai, Alvin Terry

Research output: Contribution to journalReview article

127 Scopus citations

Abstract

Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia - as well as the propensity for progressive brain changes - there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalSchizophrenia Research
Volume94
Issue number1-3
DOIs
StatePublished - Aug 1 2007

Keywords

  • Brain-derived neurotrophic factor
  • Neurotrophins
  • Relapse
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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