Neurotrophins and schizophrenia

Peter F. Buckley, Sahebarao Mahadik, Anilkumar Pillai, Alvin Terry

Research output: Contribution to journalReview article

125 Citations (Scopus)

Abstract

Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia - as well as the propensity for progressive brain changes - there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalSchizophrenia Research
Volume94
Issue number1-3
DOIs
StatePublished - Aug 1 2007

Fingerprint

Nerve Growth Factors
Schizophrenia
Neurobiology
Cholinergic Agents
Neurotransmitter Agents
Recurrence
Brain

Keywords

  • Brain-derived neurotrophic factor
  • Neurotrophins
  • Relapse
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Neurotrophins and schizophrenia. / Buckley, Peter F.; Mahadik, Sahebarao; Pillai, Anilkumar; Terry, Alvin.

In: Schizophrenia Research, Vol. 94, No. 1-3, 01.08.2007, p. 1-11.

Research output: Contribution to journalReview article

Buckley, Peter F. ; Mahadik, Sahebarao ; Pillai, Anilkumar ; Terry, Alvin. / Neurotrophins and schizophrenia. In: Schizophrenia Research. 2007 ; Vol. 94, No. 1-3. pp. 1-11.
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