Abstract
Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia - as well as the propensity for progressive brain changes - there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-11 |
| Number of pages | 11 |
| Journal | Schizophrenia Research |
| Volume | 94 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - Aug 1 2007 |
Keywords
- Brain-derived neurotrophic factor
- Neurotrophins
- Relapse
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
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Cite this
Buckley, P. F., Mahadik, S., Pillai, A., & Terry, A. (2007). Neurotrophins and schizophrenia. Schizophrenia Research, 94(1-3), 1-11. https://doi.org/10.1016/j.schres.2007.01.025