Abstract
Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia - as well as the propensity for progressive brain changes - there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-11 |
| Number of pages | 11 |
| Journal | Schizophrenia Research |
| Volume | 94 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - Aug 1 2007 |
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Keywords
- Brain-derived neurotrophic factor
- Neurotrophins
- Relapse
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Neurotrophins and schizophrenia. / Buckley, Peter F.; Mahadik, Sahebarao; Pillai, Anilkumar; Terry, Alvin.
In: Schizophrenia Research, Vol. 94, No. 1-3, 01.08.2007, p. 1-11.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Neurotrophins and schizophrenia
AU - Buckley, Peter F.
AU - Mahadik, Sahebarao
AU - Pillai, Anilkumar
AU - Terry, Alvin
PY - 2007/8/1
Y1 - 2007/8/1
N2 - Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia - as well as the propensity for progressive brain changes - there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.
AB - Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia - as well as the propensity for progressive brain changes - there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.
KW - Brain-derived neurotrophic factor
KW - Neurotrophins
KW - Relapse
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=34447131476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447131476&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2007.01.025
DO - 10.1016/j.schres.2007.01.025
M3 - Review article
C2 - 17524622
AN - SCOPUS:34447131476
VL - 94
SP - 1
EP - 11
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1-3
ER -