Neurotrophins and schizophrenia

Peter F. Buckley; Sahebarao Mahadik; Anilkumar Pillai; Alvin Terry

doi:10.1016/j.schres.2007.01.025

Neurotrophins and schizophrenia

Peter F. Buckley, Sahebarao Mahadik, Anilkumar Pillai, Alvin Terry

Research output: Contribution to journal › Review article › peer-review

133 Scopus citations

Abstract

Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia - as well as the propensity for progressive brain changes - there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.

Original language	English (US)
Pages (from-to)	1-11
Number of pages	11
Journal	Schizophrenia Research
Volume	94
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2007.01.025
State	Published - Aug 2007

Keywords

Brain-derived neurotrophic factor
Neurotrophins
Relapse
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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AU - Buckley, Peter F.

AU - Mahadik, Sahebarao

AU - Pillai, Anilkumar

AU - Terry, Alvin

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N2 - Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia - as well as the propensity for progressive brain changes - there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.

AB - Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia - as well as the propensity for progressive brain changes - there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.

KW - Brain-derived neurotrophic factor

KW - Neurotrophins

KW - Relapse

KW - Schizophrenia

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Neurotrophins and schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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