Neurovascular Injury in Acute Hyperglycemia and Diabetes: A Comparative Analysis in Experimental Stroke

Mostafa M. Elgebaly, Safia Ogbi, Weiguo Li, Erin M. Mezzetti, Roshini Prakash, Maribeth H Johnson, Askiel Bruno, Susan C. Fagan, Adviye Ergul

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Admission hyperglycemia impacts ischemic stroke deleteriously, but the relative role of acute hyperglycemia (HG) vs diabetes in the pathogenesis of this poor outcome is not clear. The study aims to determine the effect of acute HG on neurovascular outcomes of stroke under control and diabetic conditions. Moderate acute HG (140-200 mg/dl) was achieved by glucose injection before middle cerebral artery occlusion (MCAO) in control Wistar and diabetic Goto-Kakizaki rats. Following 3 h MCAO/21 h reperfusion, we measured infarct size, hemorrhagic transformation (HT) frequency, excess hemoglobin, neurobehavioral outcome, and MCA matrix metalloprotease activity. Infarct size was significantly smaller in diabetic rats. Moderate acute HG increased neuronal damage in diabetic but not in control rats. HT frequency and hemoglobin were significantly higher in diabetic rats. HG augmented vascular damage in control rats and had no additional effect on bleeding in diabetic rats. Neurological deficit was greater in diabetic rats and was worsened by HG. The finding that functional outcome is poorer in both acute HG and diabetes without a significant increase in infarct size suggests that amplified vascular damage contributes to neurological deficit in hyperglycemia. These results highlight the importance of vascular protection to improve neurological outcome in acute ischemic stroke.

Original languageEnglish (US)
Pages (from-to)391-398
Number of pages8
JournalTranslational Stroke Research
Volume2
Issue number3
DOIs
StatePublished - Sep 1 2011

Fingerprint

Hyperglycemia
Stroke
Wounds and Injuries
Blood Vessels
Middle Cerebral Artery Infarction
Hemoglobins
Metalloproteases
Reperfusion
Hemorrhage
Glucose
Injections

Keywords

  • Cerebral hemorrhage
  • Hyperglycemia
  • Ischemia-reperfusion Injury
  • MMP-9 metalloproteinase
  • Minocycline
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Neurovascular Injury in Acute Hyperglycemia and Diabetes : A Comparative Analysis in Experimental Stroke. / Elgebaly, Mostafa M.; Ogbi, Safia; Li, Weiguo; Mezzetti, Erin M.; Prakash, Roshini; Johnson, Maribeth H; Bruno, Askiel; Fagan, Susan C.; Ergul, Adviye.

In: Translational Stroke Research, Vol. 2, No. 3, 01.09.2011, p. 391-398.

Research output: Contribution to journalArticle

Elgebaly, Mostafa M. ; Ogbi, Safia ; Li, Weiguo ; Mezzetti, Erin M. ; Prakash, Roshini ; Johnson, Maribeth H ; Bruno, Askiel ; Fagan, Susan C. ; Ergul, Adviye. / Neurovascular Injury in Acute Hyperglycemia and Diabetes : A Comparative Analysis in Experimental Stroke. In: Translational Stroke Research. 2011 ; Vol. 2, No. 3. pp. 391-398.
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